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Knowledgator Engineering 142

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-passage-0", "type": "abstract", "text": [ "25 patients in every group ( steel bands versus stainless steel wires ) undergoing open heart surgery that involved median sternotomy were evaluated in a prospective randomized study . The average age of the patients and the risk factors predisposing to dehiscence were similar in both groups . In this study we looked for the problems of intraoperative handling , postoperative data and clinical follow up ." ], "offsets": [ [ 0, 408 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 3, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "steel" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038239" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "steel" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038239" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "wires" ], "offsets": [ [ 64, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005978" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "open" ], "offsets": [ [ 83, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0266061" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 88, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 94, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "stainless steel" ], "offsets": [ [ 48, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038126" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "heart surgery" ], "offsets": [ [ 88, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524727" }, { "db_name": "UMLS", "db_id": "C0018821" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 197, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 208, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 225, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 225, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 365, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] } ]

[]

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"ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r16-t9.1-t7.1", "type": "method_of", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r17-t4.1-t5.1", "type": "treats", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r18-t7.2-t9.1", "type": "issue_in", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r19-t3.1-t7.1", "type": "issue_in", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r20-t9.1-t1.1", "type": "affects", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r21-t7.2-t3.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r22-t1.1-t9.1", "type": "performs", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r23-t5.1-t7.1", "type": "issue_in", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t5", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r24-t9.1-t4.1", "type": "uses", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t9", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r25-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-t5", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s1-r26-t1.1-t4.1", "type": "uses", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "arg2_id": 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"ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-r4-t1.2-t1.1", "type": "produces", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-r5-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s3-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120117.eng.abstr-s2-t2", "normalized": [] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120121.eng.abstr-passage-0", "type": "abstract", "text": [ "Preoperative screening for aortic calcification in cardiac surgery candidates ." ], "offsets": [ [ 0, 79 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120121.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "screening" ], "offsets": [ [ 13, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220908" }, { "db_name": "UMLS", "db_id": "C0220909" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120121.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "calcification" ], "offsets": [ [ 34, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006660" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120121.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 59, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120121.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "cardiac surgery" ], "offsets": [ [ 51, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524727" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-passage-0", "type": "abstract", "text": [ "In view of a possible Stent implantation , 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated . Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters . Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters , respectively . The following results were obtained : 1. Depending on the increase in length of the infrarenal abdominal aneurysm , there is an inproportional shortening of the proximal and distal neck . Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases . 2. With lengths of more than 4 cm according to the morphological results , the distal neck is almost always unsuitable for fixation of a simple Tube-Stent . 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm . For longer aneurysms , only a quarter of all cases is suitable for stent implantation . In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions . These findings have to be considered , with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta ." ], "offsets": [ [ 0, 1567 ] ] } ]

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"db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 205, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "necks" ], "offsets": [ [ 241, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "aneurysms" ], "offsets": [ [ 254, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002940" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "necks" ], "offsets": [ [ 365, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "aneurysm" ], "offsets": [ [ 533, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002940" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "neck" ], "offsets": [ [ 609, 613 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "necks" ], "offsets": [ [ 677, 682 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 700, 705 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "morphological" ], "offsets": [ [ 781, 794 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543482" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120130.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "neck" ], "offsets": 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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120135.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction Preoperative screening , interventional , and surgical therapy of cardiovascular diseases are of crucial importance for successful peri- and postoperative treatment of abdominal aortic aneurysms ( AAA ) ." ], "offsets": [ [ 0, 217 ] ] } ]

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[]

[]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120151.eng.abstr-passage-0", "type": "abstract", "text": [ "In this study we looked at the relationship between extracorporal circulation and changes in blood electrolytes ." ], "offsets": [ [ 0, 113 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120151.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "circulation" ], "offsets": [ [ 66, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005775" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120151.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 93, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120151.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "electrolytes" ], "offsets": [ [ 99, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013832" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120151.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "in blood" ], "offsets": [ [ 90, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005768" } ] } ]

[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120157.eng.abstr-passage-0", "type": "abstract", "text": [ "In patients with an acute arterial occlusion of the right upper extremity a Doppler scanning examination should be done before balloon catheter embolectomy . If there is no arterial puls detectable , an angiography should be performed afterwards to localize the embolus . In case of a proximal arterial occlusion of the right arm we recommend this procedure to prevent an embolus dislocation by catheter embolectomy and following cerebral embolization . For direct surgical embolectomy we recommend a supraclavicular incision ." ], "offsets": [ [ 0, 527 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120160.eng.abstr-passage-0", "type": "abstract", "text": [ "Hyperlipidemia is an important factor in the development of graft vessel disease after heart transplantation . In our hospital the H.E.L.P. system ( Heparin-mediated extracorporal LDL precipitation ) was applied in heart transplanted patients with hypercholesterolemia for the first time . Indications were plasma cholesterol concentrations above 240 mg/dl and LDL-cholesterol concentrations above 135 mg/dl , respectively , in spite of cholesterol diet and maximal lipid lowering medication ( 15 mg Simvastatin/day ) . 723 treatments were performed in 13 patients . They were divided into two groups . Patients of group 1 ( n=10) showed regular coronary angiography , whereas patients of group 2 ( n=3) already revealed signs of graft vessel disease at the time of the first H.E.L.P. treatment . In the control angiographies performed once a year after H.E.L.P. was started , eight out of ten of the patients of group 1 showed no graft vessel disease , while only two out of ten developed graft vessel disease despite of H.E.L.P. therapy . In group 2 , two patients indicated a regression of preexisting angiopathy , the third patient , however , revealed further progression of coronary stenoses . Patients of both groups , who revealed no development of progression of graft vessel disease showed continously low blood levels of LDL , Lp ( a ) , and fibrinogen in the interval between two treatments . In contrast , in cases of pogressive angiopathy , a continous decrease of Lp ( a ) and fibrinogen could not be achieved with the H.E.L.P. apheresis ." ], "offsets": [ [ 0, 1554 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120167.eng.abstr-passage-0", "type": "abstract", "text": [ "The anomalous origin of the right coronary artery from the pulmonary artery is one of the rarest coronary anomalies which often remains asymptomatic until the patients achieve advanced age but may also be clinically manifest already in infants and lead to sudden death . We report the diagnostics and surgical treatment in a 15-month-old asymptomatic child and the necessity of surgical repair . The diagnosis was incidentally made during an echocardiographic procedure and confirmed by coronary angiography . A reimplantation of the ano origin of the coronary artery was carried out wihtout using extra-corporal circulation . There were no postoperative complications . Due to the coronary steal phenomenon and the related coronary risk , surgical repair is recommended also for asymptomatic cases ." ], "offsets": [ [ 0, 800 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120177.eng.abstr-passage-0", "type": "abstract", "text": [ "Recently , percutaneous dilatational tracheotomy ( PDT ) has become more frequent , since the technique can be mastered relatively easily . PDT is neither time-consuming nor does it require much personell or material . Our study seeks to evaluate PDT in terms of its effectivness and practicality on a cardio-surgical ICU ." ], "offsets": [ [ 0, 323 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-passage-0", "type": "abstract", "text": [ "The various pathogenic species of Aspergillus are ubiquitous . In the past , Aspergillus flavus was not been considered to be highly pathogenic in humans . We describe the case of a 72 year old patient whose tracheal culture tested positive for Aspergillus flavus after coronary artery bypass grafting . The indirect hemagglutinations test and the monoclonal latex antibody test had been negative ; however , the enzyme immunoassay test was positive . There was no radiological or clinical evidence of systemic infection . The patient died before administration of antimycotic therapy . The autopsy showed disseminated mycosis by Aspergillus flavus of both lungs . Due to its greater sensitivity , enzyme immunoassay testing can make detection of Aspergillus flavus easier . Since Aspergillus flavus is pathogenic in humans , we believe that intravenous antimycotic therapy with Amphotericin B should started immediately if a patient test positive in trachea culture for Aspergillus flavus ." ], "offsets": [ [ 0, 991 ] ] } ]

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"id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 926, 933 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 934, 938 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t7", "type": "umlsterm", "text": [ "trachea" ], "offsets": [ [ 951, 958 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040578" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t8", "type": "umlsterm", "text": [ "culture" ], "offsets": [ [ 959, 966 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220814" }, { "db_name": "UMLS", "db_id": "C0010453" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t9", "type": "umlsterm", "text": [ "Aspergillus" ], "offsets": [ [ 971, 982 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004034" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t10", "type": "umlsterm", "text": [ "Aspergillus flavus" ], "offsets": [ [ 781, 799 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004036" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t11", "type": "umlsterm", "text": [ "Amphotericin B" ], "offsets": [ [ 879, 893 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002679" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120182.eng.abstr-s9-t12", "type": "umlsterm", "text": [ "Aspergillus flavus" ], "offsets": [ [ 971, 989 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004036" } ] } ]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120189.eng.abstr-passage-0", "type": "abstract", "text": [ "Purpose of this study was to evaluate the clinical utility of intraoperative echocardiography in the assessment of surgical repair of congenitally malformed hearts . In 235 of 508 patients who underwent cardiac surgery during a one year period transesophageal intraoperative echocardiography was performed . This was done to exclude residual ventricular septal defects or right ventricular outflow tract obstruction ( n=84), to evaluate results of AV valve reconstruction ( n=61), to assess ventricular function following arterial switch operation for complete transposition or in complex heart defects palliated by a Fontan-type procedure ( n=50), to assess repair of left ventricular outflow obstruction ( n=22) and for miscellaneous defects ( n=18). Residual defects leading to immediate reoperation during the same surgical session were found in 4 patients ( 1.7% ) , minor residual defects not requiring reoperation were present in 6 patients ( 2.6% ) . In 2 patients with complete AV septal defect the left AV valves were only mildly regurgitant immediately after reconstruction but subsequent suture deshiscence required later reopoeration . Echocardiographic data were supplemented by direct pressure measurements in the ventricles and contrast injection into the left atrium . We conclude that intraoperative echocardiography can provide useful clinical informations , if its findings are interpreted in context with pressure measurements and contrast injections ." ], "offsets": [ [ 0, 1473 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120201.eng.abstr-passage-0", "type": "abstract", "text": [ "Hydroxymethylglutaryl coenzyme A reductase inhibitors play an important role in the propyhlaxis of coronary heart desease . A possible adverse effect is the induction of myopathies , which are described predominantly as interactions with other drugs . Two patients suffered myoglobinuria caused by rhabdomyolysis after cardiosurgical operations . In one case , a mechanical aortic valve prothesis was implanted for a combined valvular defect ; in a second case , a coronary artery bypass grafting was performed for coronary heart disease . Both patients had taken HMG-CoA reductase inhibitors before the operation . Under forced diuresis , the elevated serum concentrations of creatin kinase and myoglobin decreased continuously ." ], "offsets": [ [ 0, 730 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120206.eng.abstr-passage-0", "type": "abstract", "text": [ "Patients with severely impaired left ventricular pump function , who necessitate redo coronary bypass surgery have to face a considerably increased risk . We report on a patient who underwent redo surgery with minimal invasive techniques without extra-corporeal circulation . Indication and revascularization strategy are illustrated by the case report ." ], "offsets": [ [ 0, 354 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120210.eng.abstr-passage-0", "type": "abstract", "text": [ "This report concerns the case of a patient who had suffered a massive pulmonary embolus and for whom , despite immediately administered thrombolytic therapy with rt-PA it became necessary to initiate reanimation procedures . The patient was subsequently admitted to our cardiac surgery clinic for the purpose of operative intervention . After femorofemoral coupling on the heart-lung machine , right ventricular relieve was rapidly attained . During the course of a 3-hour period of extracorporal circulation , the initially significantly elevated pulmonary pressures were able to be reduced to moderate levels . Correspondingly , right ventricular recovery could be echocardiographically determined . As a consequence of this development , and after preclusion the presence of any large thrombotic masses which might have been situated in the pulmonary trunk , it was possible to forego thoracotomy and embolectomy . This procedure allowed , on the one hand , the avoidance of imminent right ventricular failure through the use of the heart-lung machine . On the other , due to the lessening of the degree of surgical intervention , the risk of grave hemorrhaging as a result of concurrent thrombolytic therapy could be minimalized . After an uneventful course , the patient was able to be transferred on the second postoperative day with normal pulmonary pressure values ." ], "offsets": [ [ 0, 1374 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-passage-0", "type": "abstract", "text": [ "Recently , the radial artery has gained an increasing importance as arterial graft due to its improved patency rate . The following article focuses on the clinical and anatomical peculiarities of the radial artery as well as the preparation techniques . Furthermore , the use as a composite graft with the internal mammary artery is thoroughly described ." ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 22, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "graft" ], "offsets": [ [ 77, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "radial artery" ], "offsets": [ [ 15, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162857" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "anatomical" ], "offsets": [ [ 168, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 207, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 241, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "radial artery" ], "offsets": [ [ 200, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162857" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 272, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "graft" ], "offsets": [ [ 291, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 323, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "mammary artery" ], "offsets": [ [ 315, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024661" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120214.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "internal mammary artery" ], "offsets": [ [ 306, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0226276" } ] } ]

[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-passage-0", "type": "abstract", "text": [ "Surgical closure of atrial septal defects can nowadays be performed without preoperative cardiac catheterization . For a transcatheter closure , however , x-ray exposure has been indispensable . We report a closure of an atrial septal defect under transesophageal echocardiography without fluoroscopy ." ], "offsets": [ [ 0, 302 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Surgical" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "catheterization" ], "offsets": [ [ 97, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007430" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "septal defects" ], "offsets": [ [ 27, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018816" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cardiac catheterization" ], "offsets": [ [ 89, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018795" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "atrial septal defects" ], "offsets": [ [ 20, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018817" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "defect" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "transesophageal" ], "offsets": [ [ 248, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014852" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "fluoroscopy" ], "offsets": [ [ 289, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016356" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "septal defect" ], "offsets": [ [ 228, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018816" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "transesophageal echocardiography" ], "offsets": [ [ 248, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206054" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "atrial septal defect" ], "offsets": [ [ 221, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018817" } ] } ]

[]

[]

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"ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-r12-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-r13-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-r14-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-r15-t4.1-t6.1", "type": "result_of", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.80120221.eng.abstr-s3-t4", "arg2_id": 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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-passage-0", "type": "abstract", "text": [ "A retrospective study was performed to investigate the objective and subjective results of the surgical treatment of pectus excavatum and carinatum . We carried out a modified procedure first described by M. Ravitch . The operation starts with the subperichondral resection of the rib cartilage which forms the pectus excavatum or carinatum . The fixation of the sternum is achieved by means of allogenic bone graft ." ], "offsets": [ [ 0, 417 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "retrospective" ], "offsets": [ [ 2, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 95, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 104, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "retrospective study" ], "offsets": [ [ 2, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "surgical treatment" ], "offsets": [ [ 95, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pectus excavatum" ], "offsets": [ [ 117, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 176, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 222, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "rib" ], "offsets": [ [ 281, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035561" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "cartilage" ], "offsets": [ [ 285, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007301" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "pectus excavatum" ], "offsets": [ [ 311, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "sternum" ], "offsets": [ [ 363, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038293" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 405, 409 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "graft" ], "offsets": [ [ 410, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.80120226.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "bone graft" ], "offsets": [ [ 405, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005976" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120243.eng.abstr-passage-0", "type": "abstract", "text": [ "Myasthenia gravis ( MG ) in about 80% of cases is associated with pathological alterations of the thymus . These alterations are described here with reference to distinct models of autoimmunization against the acetylcholine receptor ( AChR ) . In MG with thymitis intrathymic production of AChR-specific autoantibodies is the result of a classical antigendriven immune reaction that occurs completely inside the thymus and probably involves AChR on myoid cells as the myasthenogenic antigen . In thymoma-associated MG , intratumorous autoantibody production does not occur and intratumorous T cell activation is exceptional . Instead , abnormally hyperexpressed proteins in conjunction with abnormally low MCH class II levels may trigger autoantigen-specific , non-tolerogenic T cell selection by neoplastic epithelial cells , followed by export of potentially autoreactive T cells to extratumorous sites . Thus , the initial steps in the pathogenesis of most MG cases take place within abnormal thymic microenvironments , be they inflammatory or neoplastic . The different pathogenetic mechanisms imply that MG is an early symptom in thymitis but a late symptom in thymoma patients . Early srgery after onset of MG is essential in thymitis to prevent \" dissemination \" of autoreactive T cells to extrathymic organs and to improve MG symptoms . By contrast , \" dissemination \" of autoreactive T cells has already happend during many months or years before a given thymoma becomes symptomatic . As a consequence , surgery in thymoma patients aims mainly at the oncological and local cardiovascular complications of thymomas but rarely achieves alleviation of MG symptoms ." ], "offsets": [ [ 0, 1671 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120250.eng.abstr-passage-0", "type": "abstract", "text": [ "The typical clinical features of myasthenia gravis are weakness and excessive fatiguability of striated muscles that increases during the course of the day or after strenous exercise . Ocular muscle involvement with ptosis ( in 50% ) and diplopia ( in 25% ) are the most common initial signs . The disease can progress to bulbar muscles and to all other striated muscles ( generalized myasthenia ) . The muscle fatiguability and a fluctuating course can mislead to a diagnosis of neurasthenia . Since the treatment of myasthenia gravis is directed at the pathogenetic mechanisms of the disease an early diagnosis is of great significance for the course of the disease . Also , a false positive diagnosis of myasthenia has to be avoided because of the potentially hazardous side effects of the therapy . The mainstay of the diagnosis is the history and a subtle clinical examination with tests of excessive muscle fatiguability . The injection of edrophonium ( Tensilon ) , the electrodiagnostic testing after repitive stimulation ( decrement test ) and the testing for serum antibodies against acetylcholin receptors have to be performed to secure the diagnosis of myasthenia . The edrophonium test and the decrement test can yield false positive results in other neuromuscular diseases . Antibodies are present in 50% of ocular myasthenia and in 80-90% of the generalized form . The Lambert-Eaton myasthenic syndrome , other neuromuscular diseases , mitochondrial diseases , diseases of the cranial nerves , botulism and the rare congenital myasthenic syndromes have to be considered as differential diagnosis ." ], "offsets": [ [ 0, 1612 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120262.eng.abstr-passage-0", "type": "abstract", "text": [ "Myasthenia gravis is an neuromuscular disorder , whereas pathogenesis is an autoimmune phenomen . Nowadays thymectomy has much impact on patients follow up and has to be indicated early after diagnosis when stabilization of disease has been achieved . Radical resection of the thymus gland and ectopic tissue is mandatory for surgical sucess and improvement of the disease . Opening of both chest cavities can be helpful in operative strategy , especially for exstirpation of thymic tumors . Various maior , minor or minimal invasive surgical techniques and access are possible for thymus surgery , whereas we propagate an extended thymectomy via a complete median sternotomy ." ], "offsets": [ [ 0, 677 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120271.eng.abstr-passage-0", "type": "abstract", "text": [ "In myasthenia gravis the management of anesthesia should always be individually adapted to the severity of the disease . Current medical therapy with cholinesteraseinhibitors should be continued till the morning of surgery . Regional anesthesia is the preferrable anesthetic technique . The administration of muscle blocking agents should be avoided . This can be facilitated by the sole or additional use of spinal/epidural procedures . These will furthermore provide adequate postoperative pain relief without significant respiratory depression . If non depolarizing muscle relaxants cannot be avoided they need to be used with extreme caution and should be titrated to effect , as patients with myasthenia gravis show an increased susceptibility to these drugs . Independent of the anesthetic technique monitoring of neuromuscular function must be performed . As myasthenic patients are especially susceptible to postoperative respiratory depression they need to be observed closely for the first 24 hrs postoperatively and should have their respiratory function monitored and regularly evaluated ." ], "offsets": [ [ 0, 1101 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120276.eng.abstr-passage-0", "type": "abstract", "text": [ "Myasthenic crisis is a lifethreatening complication of myasthenia gravis due to respiratory failure and inability to swallow and cough up secretions . Frequent causes are intercurrent infections , fluctuations due to the natural history of the disease and insufficient immunosuppressive treatment prior to the crisis . Early referral to an experienced neurologist is essential . Specific therapy consists of symptomatic treatment with cholinesterase inhibitors , crisis management with plasmapheresis or immunoglobulins and immunosuppression with clucocorticoids . Infections must be treated vigorously . Thymectomy in patients with previously unrecognized myasthenia gravis is never urgently indicated and should be postponed until the patient is stabilized . In cases of impending respiratory failure and severe swallowing difficulties , early and elective admission to a specialized neurological intensive care unit and elective intubation should be performed . Adequate nursing care of intubated patients and a set of prophylactic measures are essential to avoid complications adversely affecting prognosis . Whenever it can be achieved , the best therapy of myasthenic crisis is its prevention by appropriate long-term management and follow-up of patients with myasthenia gravis ." ], "offsets": [ [ 0, 1285 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.80120282.eng.abstr-passage-0", "type": "abstract", "text": [ "The group of acquired myasthenias are autoimmune diseases , however they have different pathogenesis . Exact classification ( clinical and histological ) is important for planing and evaluation of therapeutic effects , especially thymectomy and thymomectomy . In the longterm therapy of MG patients many problems could be avoided by the knowledge of clinical characteristics ( e.g. accompanying illness , medication , vaccination ) . Other important aspects are the psychological and social situation of the patient after diagnosis and during therapy . Rehabilitation should be initiated early to enable the patient for working in his old profession if possible . The patient and attending doctors should be informed to avoid deterioration of MG and treatment of myasthenic crisis ." ], "offsets": [ [ 0, 782 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-passage-0", "type": "abstract", "text": [ "The coexistence of carotid artery stenosis with coronary artery disease occurs in a small percentage of patients requiring open heart surgical procedures . Whether the combined surgical approach favorably influences the outcome of patients requiring major cardiac operations remains controversial ." ], "offsets": [ [ 0, 298 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 27, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 34, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 57, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 64, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 104, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "open" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0266061" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 128, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 143, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "carotid artery" ], "offsets": [ [ 19, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162859" }, { "db_name": "UMLS", "db_id": "C0007272" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "surgical procedures" ], "offsets": [ [ 134, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "carotid artery stenosis" ], "offsets": [ [ 19, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007282" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "coronary artery disease" ], "offsets": [ [ 48, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010068" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "heart surgical procedures" ], "offsets": [ [ 128, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018821" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 177, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 231, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "operations" ], "offsets": [ [ 264, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130001.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "cardiac operations" ], "offsets": [ [ 256, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018821" } ] } ]

[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-passage-0", "type": "abstract", "text": [ "Atrial fibrillation ( AF ) is the most common sustained arrhythmia after extracorporeal circulation ( ECC ) . There seems to be a higher incidence of AF in patients on -blockers in the preoperative period without re-establishing this therapy after surgery . In our study we tried to determine additional factors ." ], "offsets": [ [ 0, 313 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "arrhythmia" ], "offsets": [ [ 56, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003811" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "circulation" ], "offsets": [ [ 88, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005775" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Atrial fibrillation" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004238" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "extracorporeal circulation" ], "offsets": [ [ 73, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015354" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 137, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 198, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 234, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130008.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 248, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130013.eng.abstr-passage-0", "type": "abstract", "text": [ "We investigated the incidence of postoperative chest tube bleeding , administration of blood products , and changes in coagulation tests in patients with diltiazem ( DIL ) administration for reduction of myocardial ischemic episodes during elective CABG . We retrospectively analyzed the surgical and ICU records of CABG patients who had recieved DIL ( 27 pats . ) or nitroglycerin ( NTG ; 26 pats . ) or a combination thereof ( COM ; 25 pats . ) . Data investigated included the amount of postoperative chest tube bleeding ( CTB ) , frequency of administration of packed red blood cells ( RBC ) and fresh frozen plasma ( FFP ) , and changes in hemoglobin ( Hb ) , thrombocyte ( Th ) levels as well as changes in prothrombin- ( PT ) and partial thromboplastine time ( PTT ) . There were no significant differences among the three groups with regard to biometrical or operative data . The amount of CTB as well as the use of RBC and FFP were not significantly different between the groups . Also , there were no significant differences with regard to Hb or Th and PT or PTT , both in the early phase after the operation in ICU as well as after 24 hours in the ICU . The perioperative administration of the calcium entery blocker DIL reduces the incidence of myocardial ischemia during CABG surgery . This administration during CABG surgery does not increase the risk of postoperative bleeding . As compared to NTG , DIL does not have negative effects on Hb and Th levels or the commonly used coagulation parameters in the first 24 hours in the ICU after CABG surgery ." ], "offsets": [ [ 0, 1567 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130026.eng.abstr-passage-0", "type": "abstract", "text": [ "Background Patients with cardiogenic shock refractory to pharmacological therapy have to undergo specific therapeutic procedures which often are not available in a general hospital . The transport of these patients to specialized centers can only be performed using extended circulatory support measures . We established a mobile mechanical circulatory support team responsible for the transport of selected patients to our center for further therapy ." ], "offsets": [ [ 0, 452 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130037.eng.abstr-passage-0", "type": "abstract", "text": [ "Although a variety of histologic entities were described , primary tumors of the trachea are rare findings . Over a period of 20 years , 30 patients underwent 31 tracheal resections in two hospitals for thoracic surgery . Among them 4 patients had thyroid carcinoma involving the trachea . In these patients a strumectomy combined with tracheal resection was performed . One re-operation for erosion bleeding of the innominate artery on the 8th postoperative day was successfully performed . All patients showed excellent long-term survival ." ], "offsets": [ [ 0, 542 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130046.eng.abstr-passage-0", "type": "abstract", "text": [ "This case report describes a 62 years old patient who suffered from therapy resisten atrial fibrillation for 12 years . She underwent \" Cox/Maze-III-Procedure \" during a mitral valve reconstruction and a stable sinus rhythm was achieved . Two years after operation she has been in a stable sinus rhythm . Transesophageal echocardiography revealed normal cardiac dimensions and function with coordinated atrioventricular contractility . Therefore the therapy with anticoagulants and antiarrhythmics could be discontinued ." ], "offsets": [ [ 0, 521 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130049.eng.abstr-passage-0", "type": "abstract", "text": [ "In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression ." ], "offsets": [ [ 0, 1374 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130057.eng.abstr-passage-0", "type": "abstract", "text": [ "As a consequence of scientific advances , an increasing number of patients with advanced age , reduced myocardial performance , previous cardiac surgery , comorbidities , and emergency indications are referred for cardiac surgery . This requires risk stratification to predict \" low \" , \" moderate \" , and \" high \" operative risk . Risk factors can be divided into pre- , intra- , and postoperative patient- , structure- , and procedure-related . On the basis of this risk prediction , the perioperative course can be optimized by an individually tailored multiprofessional and interdisciplinary management ." ], "offsets": [ [ 0, 608 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-passage-0", "type": "abstract", "text": [ "A decrease in compliance of the ascending aorta caused by prosthetic replacement or \" wrapping \" may lead to a partial loss of the arterial Windkessel-function . The following study investigated the effects of this intervention on aortic input impedance . In 8 pigs , the wall of the ascending aorta was wrapped with a prosthesis . This approach was chosen to minimize additional influence of extended operative procedures on the ascending aorta , like extracorporal circulation , cardioplegia or blood loss . Flow and pressure were recorded before and after the intervention , and following Fourier Transformation , the aortic input impedance was calculated . Mean pressure , mean flow , and total peripheral resistance were unaltered , while there was a significant increase in blood pressure amplitude and characteristic impedance in response to the \" wrapping \" procedure . Thus , it becomes obvious that even the loss of elastic properties of the ascending aorta only leads to an increase of left ventricular load ." ], "offsets": [ [ 0, 1020 ] ] } ]

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"ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 666, 674 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 780, 785 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 786, 794 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "impedance" ], "offsets": [ [ 824, 833 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162537" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130067.eng.abstr-s6-t5", "type": "umlsterm", "text": [ 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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130073.eng.abstr-passage-0", "type": "abstract", "text": [ "From January 1992 until December 1996 , 221 men and 79 women underwent an operation because of bronchial carcinoma ( n=197), pulmonary metastases ( n=49), other malignant tumors of the lung ( n=48) and bronchial carcinoids ( n=8). The mean age was 63.8 years . 51% of the male and 14.7% of the female patients had a bronchial carcinoma ; the histological classification of the bronchial carcinomas for men and women was squamous cell carcinoma 36.7%/8.9%, adeno-carcinoma 23.1%/40.5%, large cell carcinoma 6.8%/5.1%, small cell carcinoma 2.7%/1.3%, other malignant tumors of the lung 12.3%/3%, for pulmonary metastases 8.7%/7.7%, and for bronchial carcinoids 1.7%/1%. Above 40% of the patients had have lung diseases in their anamnesis . 52.4% were smokers ; 70.5% of the patients with squamous cell carcinoma and 71.4% with small cell lung cancer were smokers with a packyear-loading of 50. 26.3% showed complications in the postoperative time , mostly pneumonia and broncho-pleural fistula . After a mean time of 7.1 months , 64.9% of the patients showed local cancer relapses or distant metastases . The mean survival time in the case of bronchial carcinoma was 32 months ; the 5-year survival rate was 11% . For the other malignant tumors of the lung it was 14 months , and the survival rate declined to 0% after 41 months . For pulmonary metastases , the 5-year survival rate was 60.5% and for bronchial carcinoids the 31/2-year survival rate was 100% ." ], "offsets": [ [ 0, 1458 ] ] } ]

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], "normalized": [ { "db_name": "UMLS", "db_id": "C0038954" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130078.eng.abstr-passage-0", "type": "abstract", "text": [ "Recurring pneumothorax associated with menstruation was first described in 1958. In spite of the rare appearance of catamenial pneumothorax , there is no reason for underemphasized treatment . There is no universally accepted explanation for the pathogenesis of the pneumothorax . We believe that the extragenital endometriosis of the lung or diaphragm is the cause of pneumothorax . By pneumothorax , affected women often undergo several episodes before correct diagnosis is possible ." ], "offsets": [ [ 0, 486 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130083.eng.abstr-passage-0", "type": "abstract", "text": [ "We present a case of a young man with an extensive mediastinal tumor and the unexpected histopathological diagnosis of allergic granulomatosis and angiitis ( AGA , Churg-Strauss-syndrome ) . A 24-year old man was admitted to our hospital due to a massive mediastinal tumor which was already infiltrating the middle and the upper lobe of the right lung , the thymus , and the pericardial sac . The most likely diagnosis at CT was thymus carcinoma . For that diagnosis the en-bloc resection of the thymus and the middle lobe was performed and completed by a mediastinal lymphadenectomy . Parts of the upper lobe of the right lung and a 15x10cm part of the pericardial sac needed to be resected as well . The definitive histopathological result did not confirm a malignant process . After extensive immunhistochemical and molecular pathological investigations the most likely diagnosis was allergic granulomatosis associated with angiitis . Further investigations led to the diagnosis of an atypical Churg-Strauss syndrome . The problems with the clinical , histological , and immunhistochemical diagnosis are discussed and the rare conditions of the disease represented ." ], "offsets": [ [ 0, 1169 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130100.eng.abstr-passage-0", "type": "abstract", "text": [ "This is the case report of a 38 year old prison patient , who over a period of a couple of years inserted five iron wires into his chest with the intention of committing suicide . The first three wires , which were inserted in 1993 , had been left in situ without clinical problems , but the more recently inserted wires necessitated surgical intervention as a result of the patient developing pericardial tamponade and pneumothorax . Wires were removed from the left ventricle ( two wires ) , the right ventricle ( one wire ) , and the left lung ( two wires ) after thoracotomy ( median sternotomy ) with the use of the extracorporal circulation ( heart-lung machine ) . The patient was removed after a short stay on the surgical ward . He was hemodynamically stable and exhibited no signs of infection necessitating further surgical intervention ." ], "offsets": [ [ 0, 849 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130107.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The best operative approach for concomitant carotid artery and cardiac disease remains controversial . Many studies proved the safety and efficiency of simultaneous surgery . We aimed to demonstrate the same benefits for patients > = 70 yrs ." ], "offsets": [ [ 0, 257 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130114.eng.abstr-passage-0", "type": "abstract", "text": [ "Neuro-ophthalmological complications after extracorporal circulation are rarely described in the literature . Retinal infarction , retinal embolization , cerebral ischemia , Horner's syndrome , and acute ischemic opticus-neuropathy's are possible differential diagnosis ." ], "offsets": [ [ 0, 271 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130121.eng.abstr-passage-0", "type": "abstract", "text": [ "Twelve non-consecutive patients aged between 5 and 19 years with univentricular heart and hypoplastic pulmonary artery bed , who early in life underwent systemic-to-pulmonary shunt for augmentation of pulmonary artery diameter , and after normalization of pulmonary artery size a Fontan procedure , were enrolled in the study . The inclusion criteria were normal pulmonary vascular resistance , competent atrio-ventricular valve ( s ) , and globally unimpaired ventricular function . All patients were grouped according to the level of the pulmonary artery flow : restrictive QP : Qs 1.0 ( n=6), balanced QP : Qs=1.0 ( n=3), and excessive Qp : Qs > 1.0 ( n=3). In each patient , for assessment of the development of the proximal segments of the pulmonary arteries the Nakata-index and McGoon-ratio , and for assessment of the medial and distal segments of the pulmonary artery a selfdeveloped computer assisted planimetric area calculation - index ( PPAAI ; cm2/m2 b.s.a. ) were analyzed in correlation to the level of the pulmonary flow index ( Qpi ) . The cardio-pulmonary situation was assessed by following parameters : Hb , Sasat%, Qp/Qs , PAP , Rp/Rs , EDVP , FS%, and ventricular diastolic compliance ( VC=EDVP/Qpi+Qsi). There was a positive correlation between the pulmonary flow index ( Qpi ) and the Nakata- and McGoon-values suggesting a prognostic relevance of the Qpi in the assessment of the tendency of development of the pulmonary artery diameter . There was no correlation between Qpi and PPAAI , the planimetrically assessed pulmonary vessel areas in patients with restrictive and excessive pulmonary artery flow were comparable . In conclusion , the Nakata-index is due to the shunt related distortion of the proximal segment of the pulmonary artery a non-reliable factor in the assessment of the degree of development of the pulmonary artery tree . The assessment of the medial and distal pulmonary artery segments seems to be more valid and should be considered for optimal timing for definite surgery ." ], "offsets": [ [ 0, 2024 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130126.eng.abstr-passage-0", "type": "abstract", "text": [ "In Europe , saprophytic pulmonary aspergillosis represents the only mycotic infection relevant for thoracic surgery . From the pathogenetic point of view , it is a colonization of preexisting lung or pleural cavities following other severe pulmonary diseases . The incidence amounts to 0.4% among patients in a special hospital for pulmonary diseases . Concerning this review , the diagnosis is based on histologic examination for all 66 patients we operated on between 1961 and 1996. Preoperative proof of the fungal infection remains difficult . The majority of patients ( 77% ) are male . There is a correlation between cigarette smoking and abuse of alcohol on the one hand and the incidence of the disease on the other hand . A higher incidence of saprophytic pulmonary aspergillosis was found for people working in agriculture , in the building trade , and in paper mills . Pulmonary tuberculosis and pneumonia were present in the past history in 47% of the patients . Usually , the tentative diagnosis is based on chest x-ray , especially if hemoptysis is present . Major hemoptysis is the most severe and most dangerous complication caused by aspergilloma . Clinical presentation and chest x-ray findings are non-characteristic . Nowadays , the typical x-ray of pulmonary aspergilloma , almost always localized in the upper lobes , became a rare finding . If an aspergillus infection is suspected , serologic methods are reliable and sensitive . A surgical procedure is absolutely indicated in patients with major hemoptysis in their history , in case of disease progression or indeterminate mass and in order to avoid fungal dissemination . If a saprophytic aspergillosis is suspected according to radiologic findings , clinical examination , and patient's social history , an operation is justified . Relative surgical indications are hepatotoxic and carcinogenic effects of the mycotoxins . The lobectomy , if necessary carried out as pleuro-lobectomy , is the adequate resection in most patients ( 68% ) . However , this operation is technically demanding and it usually requires a longer operating time as compared to lobectomies for other underlying diseases . Peri- and postoperative complications occur in 60% of resections for pulmonary aspergilloma . A higher incidence of postoperative complications was found for smaller resections , like segmentectomies or wedge resections , as compared to lobectomies . Persistent pleural space problems connected with a prolonged stay in the hospital remains the main problem . It requires a primary or secondary thoracoplasty in a number of patients . The operative mortality rate is 3% . A systemic antifungal therapy is not an appropriate treatment for saprophytic pulmonary aspergillosis and can even cause specific complications ." ], "offsets": [ [ 0, 2792 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130133.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : An investigation into CT-controlled carve-suction biopsy for a histological clarification of indefinite intrathoracic masses ." ], "offsets": [ [ 0, 136 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130133.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "biopsy" ], "offsets": [ [ 60, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220797" }, { "db_name": "UMLS", "db_id": "C0005558" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-passage-0", "type": "abstract", "text": [ "A potential impact of tricyclic antidepressants on oral anticoagulation is controversial . Phenprocoumon - the most commonly used anticoagulant in Germany - is rarely considered in clinical trials . In the present study , a potential drug-drug interaction between phenprocoumon and tricyclics , causing an alteration in prothrombinemic effects , has been investigated ." ], "offsets": [ [ 0, 369 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "antidepressants" ], "offsets": [ [ 32, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003289" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "anticoagulation" ], "offsets": [ [ 56, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003209" }, { "db_name": "UMLS", "db_id": "C0003204" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "anticoagulation" ], "offsets": [ [ 56, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005790" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "tricyclic antidepressants" ], "offsets": [ [ 22, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003290" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Phenprocoumon" ], "offsets": [ [ 91, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031444" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "anticoagulant" ], "offsets": [ [ 130, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003280" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 147, 154 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "clinical trials" ], "offsets": [ [ 181, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008976" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "interaction" ], "offsets": [ [ 244, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037420" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "phenprocoumon" ], "offsets": [ [ 264, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031444" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "drug-drug interaction" ], "offsets": [ [ 234, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687133" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r1-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r2-t3.1-t2.2", "type": "analyzes", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r3-t3.1-t4.1", "type": "analyzes", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r4-t4.1-t2.2", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r5-t4.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r6-t3.1-t2.1", "type": "analyzes", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s1-r7-t3.1-t1.1", "type": "analyzes", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r1-t4.1-t2.1", "type": "measures", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r2-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r3-t4.1-t1.1", "type": "measures", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r4-t4.1-t1.1", "type": "uses", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r5-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-r6-t4.1-t2.1", "type": "uses", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s2-t4", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-r1-t1.1-t3.1", "type": "affects", "arg1_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t1", "arg2_id": "ZfuerHerzThoraxGefaesschirurgie.90130139.eng.abstr-s3-t3", "normalized": [] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : The relationship between disease-free interval ( DFI ) and the prognosis of patients with pulmonary metastasis has been discussed controversely . There is only poor information about patients with long-term DFI . In our study , we analyzed the cases of pulmonary metastasis with DFI longer than 5 years ." ], "offsets": [ [ 0, 317 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "disease-free" ], "offsets": [ [ 38, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 76, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "metastasis" ], "offsets": [ [ 113, 123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 196, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130147.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "metastasis" ], "offsets": [ [ 276, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] } ]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130151.eng.abstr-passage-0", "type": "abstract", "text": [ "A 38 year old male patient with a coarctation of the aorta was successfully operated using an ascending aorta-abdominal aorta bypass ( AAAAB ) . The diagnosis of a severe postisthmic stenosis had been confirmed by aortography . Preoperatively the patient suffered from extreme hypertension and claudicatio intermittens . After prosthetic repair of coarctation , blood pressure became normotensive and claudicatio intermittens disappeared . In this report , we discuss various surgical techniques and the most important question concerning the optimal timing of surgical repair of aortic coarctation ." ], "offsets": [ [ 0, 600 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130169.eng.abstr-passage-0", "type": "abstract", "text": [ "From January 1983 through December 1996 , 112 adult patients ( the age ranged from 17 to 67 years , mean 41 years ) were operated for an ASD at the \" Klinik fuer Herz- und Thoraxchirurgie der Universitaet Wuerzburg \" . This retrospective study analyzed the pre- , intra- , peri- , and postoperative data after surgical closure of the ASD in 73 female ( 65% ) and 39 male ( 35% ) patients . Most common was the ASDII with 79% ( 89/112 patients ) . 18% ( 20/112 patients ) were treated because of a SVD and only 3% due to an ASDI . The results of the postoperative cases of 110/112 patients ( 98% ) were collected with a follow-up period between 8 months and 14 years , a mean follow-up of 8 years . The results showed that the pressure in the right heart and in pulmonary hypertension increased with age ( p 0.05 ) as well as in heart failure ( measured in NYHA classes ) ( p 0.05 ) . Intraoperative data such as the length of operation ( 145 +/- 38min . ) , bypass ( 53 +/- 28min . ) , and ischemia period ( 29 +/- 17min . ) were independent of age as well as ( preoperative measured ) hemodynamic data . Two patients were operated once again because of a persistent shunting in the follow-up period . No patient died during the intra- or perioperative time . One patient died 8 years after the surgical closure due to congestive heart failure at the age of 75. Postoperatively , heart failure significantly improved ( p 0.05 ) . The average preoperative NYHA class of 2.6 improved to 1.7 postoperatively . The patient's state of health in the follow-up period improved after the operation in 83/110 cases ( 76% ) . 20/110 patients ( 18% ) did not feel a change and 7/110 patients ( 6% ) felt a negative change in their state of health . The results from this study point out that the operative closure of the defect even at an older age is an operation with a mortality less than 1% and there is a benefit in operation . Parameters like the age of the patients or increasing pulmonary hypertension are actually no reason to refuse patients for operation . A corrective operation is not indicated any more if the pulmonary resistance had led to an Eisenmenger reaction . The optimal time for operation is a young age in order to prevent paradox emboli and pulmonary hypertension with their complications ." ], "offsets": [ [ 0, 2305 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130175.eng.abstr-passage-0", "type": "abstract", "text": [ "Aortic valve procedures are generally performed via a median sternotomy . Minimally invasive concepts in cardiac surgery have been developed and alternative procedures for cardiac valve repair/replacement using a partial sternotomy , limited right or left thoracotomy or a transverse sternotomy have been introduced ( minimal access techniques ) . The extracorporeal circulation is established either via this minimal access or via the femoral vessels . We investigated 26 patients undergoing a minimal access procedure for aortic valve repair/replacement using a J-shaped upper partial median sternotomy concerning the procedure-associated morbidity . Reduction in blood loss ( range 15-500ml) and reduced transfusion need ( range 0-5units/pt) as well as advantages concerning reduction of postoperative pain , pulmonary complications and improved mobilization were found . In the hospital , mortality was 0% . Our preliminary results show that aortic valve repair/replacement using a minimal access technique is a demanding procedure which may reduce perioperative morbidity in selected patients . The different minimal access techniques in the literature are discussed and compared concerning their characteristic features ." ], "offsets": [ [ 0, 1227 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130185.eng.abstr-passage-0", "type": "abstract", "text": [ "In intensive care medicine , percutaneous tracheostomy is internationally recognized as a practicable and safe alternative to conventional surgical tracheostomy . This also holds true for Fantoni's translaryngeal technique ( TLT ) . Nonetheless , there are a number of reports of technical problems in the performance of TLT , especially with regard to the retrograde passage of the guide wire and the rotation of the cannula . We modified TLT in that the guide wire was passed retrograde through the endotracheal tube under videobronchoscopic control . Also , prior to rotation of the tracheal cannula , its position was verified by laryngoscopy and corrected if necessary . Feasibility of these modifications were analyzed in terms of operating time and oxygenation of the patient . 25 patients underwent modified TLT on our cardiosurgical ICU . Operating time was 4.8 +/- 3.9 minutes on the average . This is more than 50% below reported operating times in previous studies . During the procedure , there were no significant changes in PaO2 or oxygenation index ( PaO2/FiO2). Also , there were no technical problems or complications . Our modifications enhance the safety and practicability of TLT as compared to the original technique . Nonetheless , a definitive evaluation will have to await the publication of studies with a larger number of patients ." ], "offsets": [ [ 0, 1359 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130192.eng.abstr-passage-0", "type": "abstract", "text": [ "A young patient who underwent renewed aortic valve replacement after already open blasting of the aortic valve and following valve replacement with enlargement of the ascending thoracic aorty by using a pericardium patch had taken place is reported . In the area of this enlargement by the pericardium patch , the development of an aneurysm was seen and was resected in the same setting without any difficulties . The particular items with special regard to the postoperative course are delineated in the following report ." ], "offsets": [ [ 0, 523 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130195.eng.abstr-passage-0", "type": "abstract", "text": [ "Severe pulmonary hemorrhage ( hemoptysis ) is a life-threatening condition , despite the recent development of intensive care management ( 6 ) . Considering different definitions , an amount of 1000ml/24h or 150ml/h is regarded as severe hemoptysis ( 13 ) . In recent years we have seen a change in predisposing factors , with an inflammatory disorder being the cause of 90% of all nontraumatic cases ( 5,9 ) . Patient with severe valvular dysfunction , especially mitral stenosis , ravel suffer from hemoptysis . Following thrombolytic therapy hemoptysis as a severe complication is seen in only 0.4% ( 2 ) . We now report on a patient who had several frustrane thrombolytic therapies for Re-Re-Rethrombosis of his mechanical prosthetic mitral valve and experienced massive hemoptysis during emergency mitral valve replacement . Rinsing the patient's bronchial tree with ice-cooled isotonic saline and epinephrine , positive endexpiratory pressure ( PEEP ) ventilation and local bronchial tamponade with epinephrine soaked gauze swabs , left the patient's pulmonary bleeding unabated . Therefore we decided to transform the cardiopulmonary bypass into a thoracic arterio-venous ECMO/ECCO ( extracorporeal membrane oxygenation and -CO2 elimination ) and thereafter performed a tamponade of the whole tracheo-bronchial tree with epinephrine soaked swabs . With this treatment the patient's hemoptysis finally seized and successive removal of the bronchial tamponade became feasible . Subsequently we resumed mechanical ventilation and the ECMO was successfully explanted . To our knowledge , this is the first report of a successful treatment of severe pulmonary hemorrhage with a lung assist system ( LAS ) ." ], "offsets": [ [ 0, 1708 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130203.eng.abstr-passage-0", "type": "abstract", "text": [ "Primary vascular leiomyosarcoma is a rare soft tissue tumor . In most cases diagnosis is done during or postoperation . The only effective therapy is a radical tumor resection . This is a case report of a patient with a primary leiomyosarcoma of the inferior caval vein with a follow up of about 5 years ; usually the overall prognosis is still poor . Diagnosis , therapy and prognosis are discussed . Because no effective adjuvant chemotherapy or radiation is available , diagnosis before operation is important for a radical tumor resection ." ], "offsets": [ [ 0, 544 ] ] } ]

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"db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130203.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 139, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130203.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 160, 165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130203.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 205, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130203.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "leiomyosarcoma" ], "offsets": [ [ 228, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": 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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130209.eng.abstr-passage-0", "type": "abstract", "text": [ "Heparin-induced thrombocytopenia ( HIT ) is the most important side-effect of heparin therapy . Two types of thrombocytopenia can be caused by heparin : a frequent non-immunologic type causing a minor decrease in thrombocyte count without apparent clinical importance and , on the other hand , an immunologic type accompanied by thromboembolic complications . Patients and methods : We report on two cases with HIT type II after coronary artery bypass grafting ( CABG ) . HIT antibodies were demonstrated by ELISA for platelet-factor-4-heparin-complex and heparin-induced platelet-activation ( HIPA ) assay . Results : A 67 year old patient suffered from a HIT type II seven days after administration of heparin during myocardial revascularization . In this patient , a continuous fever and a signicantly reduced general condition were the primary symptoms . The clinical picture of this disease was reversible after aborting the heparin therapy . Thromboembolic complications did not occur . A 70 year old patient developed a HIT type II with thromboembolic complications 13 days after CABG . The vascular occlusions affected the A. spinalis anterior with the development of a spinalis anterior-syndrome , the coronary arteries with the development of myocadial infarction , and the A. iliaca interna . A white-clot syndrome with thrombi in the ascending aorta , in the left atrium , and in the left ventricle required an operation with extracorporal circulation including the use of recombinant hirudin for anticoagulation . Conclusion : With therapy with heparin , it is obligatory to check platelet count . An indication for the development of HIT type II is a decrease in platelet count or thromboembolic complications during heparin therapy . In the case of HIT type II recombinant hirudin was a practical altenative as an anticoagulant for extracorporal circulation and for continous hemofiltration ." ], "offsets": [ [ 0, 1907 ] ] } ]

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"offsets": [ [ 1731, 1738 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019134" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130209.eng.abstr-s13-t5", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 1739, 1746 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130209.eng.abstr-s13-t6", "type": "umlsterm", "text": [ "platelet count" ], "offsets": [ [ 1677, 1691 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032181" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130209.eng.abstr-s14-t1", "type": "umlsterm", "text": [ "hirudin" ], "offsets": [ [ 1788, 1795 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019573" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130209.eng.abstr-s14-t2", "type": "umlsterm", "text": [ "anticoagulant" ], "offsets": [ [ 1829, 1842 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003280" } ] }, { "id": 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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130215.eng.abstr-passage-0", "type": "abstract", "text": [ "The use of extracorporal circulation in open heart surgery causes profound stimulation of proinflammatory reaction . Therefore , timely diagnosis of infectious complications may become extremely difficult , and a more reliable marker of sepsis under these circumstances is needed . We measured the new marker for sepsis Procalcitonin ( PCT ) in two distinct groups of patients exposed to extracorporeal circulatory devices . Group VAD consisted of 38 patients in end-stage heart failure supported with ventricular assist devices ( VAD ) Type Berlin Heart . Group EEC included 713 patients undergoing standard open heart surgery procedures . PCT was measured before operation and daily thereafter . PCT levels before operation were able to identify patients in cardiogenic shock who after device implantation died of infectious complications . Patients on VAD who showed elevated PCT levels before heart transplantation had a very unfavorable outcome . In the ECC group , none of the patients had elevated PCT levels before surgery . On day one after the procedure PCT was elevated in those patients who in their further postoperative course developed complications . Patients without PCT elevation after open heart surgery had an uncomplicated recovery . Under the conditions of cardiogenic shock as well as the use of extracorporeal circulation , PCT is able to identify bacterial and fungal infections . It is helpful in evaluating the transplantability of patients on VADs . PCT seams to be unaffected by the use of extracorporeal circulatory circuits . However , a substantial number of patients exhibit PCT increase after ECC , and the PCT level has some prognostic value . The increase of PCT may be due to intestinal malperfusion ." ], "offsets": [ [ 0, 1738 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-passage-0", "type": "abstract", "text": [ "Coumarin necrosis is a rare , but life-threatening complication when administering coumarin in oral anticoagulant therapy . Predestined areas are the breasts , hips , gluteal region , thighs or lower legs . Thrombotic tendencies , such as congenital or acquired changes in coagulation , lead to a higher risk of coumarin necrosis . A direct , toxic effect of coumarin on the capillary system may also play a role . Although the incidence is only 0.01-0.1%, lethality lies at 15% , the knowledge of this rare complication is important in order to begin with a proper treatment punctually . The therapy of choice is early fibrinolysis ." ], "offsets": [ [ 0, 634 ] ] } ]

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"C0039866" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "legs" ], "offsets": [ [ 200, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "gluteal region" ], "offsets": [ [ 167, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282082" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "congenital" ], "offsets": [ [ 239, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009678" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "coagulation" ], "offsets": [ [ 273, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005790" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130228.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 304, 308 ] ], "normalized": [ { 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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130241.eng.abstr-passage-0", "type": "abstract", "text": [ "We report the case of a patient with suspected strut failure of a 28 year old Starr-Edwards aortic prosthesis . The physical characteristics of the former Starr-Edwards ball prosthesis are discussed ." ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130241.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 24, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130241.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 74, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130241.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "prosthesis" ], "offsets": [ [ 99, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525024" }, { "db_name": "UMLS", "db_id": "C0175649" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130241.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "prosthesis" ], "offsets": [ [ 174, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525024" }, { "db_name": "UMLS", "db_id": "C0175649" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-passage-0", "type": "abstract", "text": [ "Aortic root abscesses are a well-known and serious complication of infective endocarditis . The echocardiographic recognition of abscesses has been described by Mardelli and others . As with other diseases , there have been asymptomatic cases of endocarditis reported , but there are no reports about asymptomatic abscess formation ." ], "offsets": [ [ 0, 333 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "abscesses" ], "offsets": [ [ 12, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000833" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 51, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 77, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infective endocarditis" ], "offsets": [ [ 67, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014121" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "recognition" ], "offsets": [ [ 114, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524637" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "abscesses" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000833" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Mardelli" ], "offsets": [ [ 161, 169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242747" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 197, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 246, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130244.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "abscess" ], "offsets": [ [ 314, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000833" } ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130249.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospective study 97 patients with intraoperative low output syndrome , who were operated with heart-lung bypass and received an implantation of an intraaortic ballon pump , were analyzed . All operations were performed between July 1996 and July 1997. Sixty operations were elective and 37 patients were operated in an emergency situation . Twenty-nine of all patients died perioperatively . Sixty-eight patients could be discharged from the hospital . Patients who died perioperatively were significantly older , had a significantly lower LVEF pre- and perioperatively , had a higher catecholamines demand despite the IABP support , were anuric or nearly anuric , had a lower cardiac index , and the total bypass time was significantly longer . All five patients who had received mitral valve procedures died . We conclude that the success or failure of perioperative IABP support can be predicted early after implantation . In patients with low output syndrome despite the IABP support , an implantation of a ventricular assist system should be considered ." ], "offsets": [ [ 0, 1065 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130255.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective : In ischemic cardiomyopathy ( ICM ) alterations of the phenotype of myocyte are responsible for critical changes in the intracellular Ca2+-handling. These changes can substantially influence myocardial performance and favor ventricular arrhythmia . Therefore , we investigated whether and how changes in preload , afterload and frequency effect contractility , diastolic Ca2+-handling and resting tension in isolated human myocardium from patients with ICM . Methods : Small muscle strip preparations ( 0.5x5.0mm) were obtained from non-failing ( NDH , n=11) and from non-infarcted areas of failing human hearts ( ICM , n=8). Preparations were loaded with the Ca2+-indicator FURA-2 and mounted between a force transducer and servomotor ( organ bath : 37 °C, oxygenated KHS ) . The influence of stimulation frequency ( 0.5-3Hz), preload ( 0.8-1.5L/Lmax) and afterload on force , passive resting tension and diastolic Ca2+-handling was measured . Results : 1 ) In NDH , peak isometric force was observed at 2Hz . In contrast , the ICM-myocardium developed maximum isometric force at 1Hz . At higher stimulation rates twitch tension was significantly reduced in ICM ( p 0.0001 ) . 2 ) Diastolic Ca2+-levels were elevated ( p 0.0001 ) at higher stimulation frequencies ( > 1.5Hz ) , associated with parallel increase of diastolic resting tension in ICM ( p 0.0001 ) . 3 ) With increasing preload , force increased in NDH- and in ICM-myocardium . No significant difference in active force generation was observed ( n.s. ) . 4 ) Passive resting tension was considerably elevated in ICM ( p 0.0001 ) . 5 ) During shortening , diastolic Ca2+-levels were significantly elevated in ICM ( p 0.0001 ) . Conclusions : The function of the Frank-Starling-Mechanism is maintained in ICM , whereas a negative force-frequency relationship and a disturbed diastolic Ca2+-homeostasis, which is associated with alterations in resting tension , may contribute to the impairment of myocardial performance in end-stage ischemic cardiomyopathy ." ], "offsets": [ [ 0, 2031 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130267.eng.abstr-passage-0", "type": "abstract", "text": [ "Hemorrhage after cardiopulmonary bypass ( CPB ) is associated with increased fibrinolytic and clotting activity . As pathogenic factors artificial ( nonbiologic ) surface contact and damage of corpuscular blood components are discussed . The aim of this study was to evaluate the impact of heparin-coated circuits on coagulation and fibrinolytic parameters , platelet count and postoperative blood loss in low-risk cardiac patients . Fifty-two patients undergoing coronary artery bypass grafting ( CABG ) were randomly assigned to totally heparin coated ( BiolineTM , Jostra , Hirrlingen , Germany ) or identical uncoated extracorporeal circuits in a double blind protocol . Initial heparin dosage was equal for coated and uncoated circuits . Systemic anticoagulation was maintained with heparin in both groups . Coagulation and fibrinolytic parameters showed a parallel perioperative course . Postoperative platelet count was significantly higher with heparin coating ( 152000/µl +/- 46000 vs. 125000/µl +/- 44000 , p=0.029). Blood loss was lower with heparin coating but did not reach statistical significance . Heparin consumption was not reduced in heparin-coated circuits . Heparin coating of cardiopulmonary bypass circuits does not improve hemostatic disorders in low risk CABG patients . Higher postoperative platelet counts suggest clinical benefit for high-risk patients with extended duration of bypass . Our data do not support reducing systemic heparin doses with heparin-coated circuits ." ], "offsets": [ [ 0, 1502 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-passage-0", "type": "abstract", "text": [ "The coarctation of the aorta is a congenital narrowing of the aorta in the transitional area between the distal aortic arch and the proximal descending aorta . The coarctation causes an arterial hypertension of the upper half and an arterial hypotension of the lower half of the body . The indication for operative repair is given because of the hypertension with strain and possible insufficiency of the heart . The resection of the narrowed part of the aorta with end-to-end anastomosis or interposition of a prosthesis brings on the risk of a recoarctation . After a Vosschulte-aortoplasty a recurrent coarctation is rarely seen . This method , however , brings on a higher risk of the development of an aneurysm . In the following it is reported about a patient who underwent an operation due to an aneurysm 22 years after a Vosschulte-aortoplasty ." ], "offsets": [ [ 0, 853 ] ] } ]

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"C0003489" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "descending aorta" ], "offsets": [ [ 141, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011666" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 195, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "hypotension" ], "offsets": [ [ 242, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020649" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "arterial hypotension" ], "offsets": [ [ 233, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020649" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "repair" ], "offsets": [ [ 315, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043240" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 346, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "strain" ], "offsets": [ [ 364, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080194" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 405, 410 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "aorta" ], "offsets": [ [ 455, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003483" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "prosthesis" ], 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"ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 689, 700 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "aneurysm" ], "offsets": [ [ 707, 715 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002940" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 677, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 758, 765 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 783, 792 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.90130273.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "aneurysm" ], "offsets": [ [ 803, 811 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002940" } ] } ]

[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.90130277.eng.abstr-passage-0", "type": "abstract", "text": [ "Purpose : The purpose of this study is to compare surgical treatment of extracranial carotid aneurysms with endovascular treatment using stents and coils or stentgrafts . Methods : In a retrospective study the data from 19 patients with 22 extracranial carotid aneurysms between 1987 and 1999 were analyzed . Annual clinical follow-up using duplex sonography and in some cases angiographic control was done . Results : Fourteen aneurysms were reconstructed surgically , endovascular treatment was performed in eight cases . A temporary lesion of cranial nerves occurred in 26.6% , a permanent lesion in 6.6% of the surgically treated group . No neurological deficits were apparent . In the patient group which underwent endovascular treatment , 12.5% had a cerebral neurological deficit . In one case the treatment of a stenosis was necessary after 14 months . Conclusions : Surgical reconstruction of extracranial carotid aneurysms is the method of choice . Endovascular treatment should be considered when aneurysms are inoperable or located high at the cranial base ." ], "offsets": [ [ 0, 1070 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s001.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Stentless porcine aortic valves are considered to be hemodynamically superior to mounted bioprostheses . Methods : From May 1996 to June 1997 , 58 consecutive patients underwent aortic valve replacement with the Freestyle stentless bioprosthesis in the subcoronary position . Mean age was 73,8 years ( range 61-84 ) . The predominant aortic valve lesion was stenosis in 29 and regurgitation in 10 cases . A combined lesion was found in 19 patients . All patients were examined clinically and by echocardiography 1 week , 6 months , and 1 year postoperatively . Results : Additional coronary artery bypass grafting was performed in 26 patients . Mean cross-clamp time was 55 min ( range 41-95 ) for AVR and 71 min ( range 52-103 ) with additional CABG . The inhospital mortality rate was 7% ( 4/58 ) . Thromboembolism , hemorrhage , endocarditis or structural valve deterioration did not occur . At one year 41% were in NYHA class I , 53% in NYHA class II . Minimal aortic valve incompetence was seen in 19% postoperatively , in 14% at 6 months and in 9% at 1 year . There was no case of severe regurgitation . Conclusions : The Freestyle stentless bioprosthesis shows good results both hemodynamicaly and clinically . Pressure gradients are decreasing and most of the Patients are in NYHA functional class I or II postoperatively . Perioperative mortality is low and no valve related complications occured suggesting this type of valve to be safe . Whether this promising valve can live up its expectations has yet to be determined in long-term follow-up studies ." ], "offsets": [ [ 0, 1577 ] ] } ]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s007.eng.abstr-passage-0", "type": "abstract", "text": [ "We present the case of a 52-years old patient , in whom an implantable cardioverter/defibrillator ( ICD ) had to be implanted in 1996 for reason of recurrent ventricular tachycardia . The patient developed an infection of the system , which therefore needed to be explanted . The attempt to replace a transvenous system a few days later was not successful , because there was a complete thrombosis ( clinical asymptomatic ) of the central venous system , including the superior vena cava . We then placed the lead directly via the right atrium performing a small anterior right-sided thoracotomy through the 4th intercostal space . The device was placed subpectoral on the right side and functioned as well as a left sided device . This procedure seems us to be less harmful than the alternative of placing epicardial patches ." ], "offsets": [ [ 0, 827 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s018.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The use of extracorporeal circulation ( ECC ) in cardiac surgery can cause hypercirculatory cardiac failure ( HCF ) . ECC induced release of inflammatory mediators is one mechanism responsible for HCF . Additionally , hemodilution itself can cause a decrease in systemic vascular resistance . Therefore , we prospectively studied the effects of different venous drainage techniques on the incidence of hypercirculatory cardiac failure . Methods : After ethical approval and written informed consent , 120 patients scheduled for CABG surgery were randomized into three groups : group A : single atrial cannulation ; group B : single atrial cannulation combined with intraoperative hemofiltration to zero fluid balance , and group C : bicaval cannulation with complete venous drainage of cardioplegic solution . Cardioplegia was performed with 2 L of Bretschneider HTK solution into the aortic root . Bypass grafting was performed in moderate hypothermia ( 32 °C). Hemodynamics , use of vasoactive drugs , plasma electrolytes , body temperature , and hemoglobin/hematocrit ratio were recorded . HCF was defined as cardiac output ( CO ) > 6 l min-1, systemic vascular resistance ( SVR ) 800 dyn sec cm-5 and mean arterial pressure ( MAP ) 60 mm Hg. Statistical analysis was performed using multiple analysis of variance for repeated measures ( MANOVA ) . A level of p =0 . 05 was considered significant . Results : No perioperative mortality was observed in the three groups . The incidence of HCF was significantly higher in group A ( 32% , n=13) and B ( 40% , n=16) compared to group C ( 10% , n=4) ( p 0.05 ) . Cardiac output in patients with HCF was significantly higher than in patients with No-HCF ( Gr . A : 8.2 +/- 1.1 vs. 6.0 +/- 1.3 , Gr . B : 7.8 +/- 0.8 vs. 4.7 +/- 0.9 , Gr . C : 7.4 +/- 4.6 ; p 0.05 ) . In correlation systemic vascular resistance was decreased in patients with HCF ( Gr . A : 575 +/- 86 vs. 992 +/- 232 , Gr . B : 603 +/- 157 vs. 1134 +/- 257 vs. 725 +/- 172 vs. 1325 +/- 297 ; p 0.05 ) . Statistical analysis revealed no interaction between HCF and hematocrit , body temperature , plasma levels of sodium and calcium or other hemodynamic parameters like pulmonary artery pressure , pulmonary vascular resistance or heart rate . Conclusions : The results of the present study suggest that single atrial cannulation results in a significantly higher incidence of HCF when compared to bicaval cannulation . A possible explanation for the higher incidence of HCF in group A and B might be the inevitable infusion of cardioplegic solution into the systemic circulation . Perioperative zero flow balanced hemofiltration does not prevent HCF ." ], "offsets": [ [ 0, 2681 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s025.eng.abstr-passage-0", "type": "abstract", "text": [ "Although the incidence of postpneumonectomy bronchopleural fistula has decreased in recent years due to new surgical refinements and a better understanding of the bronchial stump healing it remains a major problem . We reviewed our most recent experience on BPF after pneumonectomy to determine methods by which the risks may effectively be reduced . From 1983 to 1997 , 315 patients underwent pneumonectomy for lung cancer , and other malignancy and benign causes ( infection with destroyed lung ) . Main bronchial manual suture was performed in 204 cases and stapled suture in 111 cases . The overall main BPF rate was 3.7% ( 12/315 ) . The mortality rate was high with 38.4% ( 5/12 ) . Death was caused by aspiration pneumonia and ARDS in 3 , empyema with sepsis and cachexia in 1 , and distant tumor recurrence in 1 patient . Risk factors for BPFs were right pneumonectomy ( p=0.03) and barotrauma due to postoperative mechanical ventilation ( p=0.003). Other previous mentioned risk factors like age , preoperative infection and/or radiation , diabetes mellitus , steroid medication reached no statistical significance . Primary reexploration through the previous thoracotomy incision was performed in 9 patients . After debridement and refashioning the bronchial stump was reclosed with the hand suture technique . The stump was covered with intercostal muscle in 5 , pericardial fat pad in 3 , and omental flap in 2 patients . Three cases with a pinhole fistula and poor overall condition were treated endoscopically using fibrin sealant and spongy iliacal bone . In 2 patients the fistula persisted and the stump had to be surgically reclosed . Conclusions : Postpneumonectomy BPF is one of the most serious complications after lung surgery associated with a high mortality . BPF is more common after right pneumonectomy and is frequently associated with postoperative mechanical ventilation . Rethoracotomy with refashioning , reclosure and covering of the bronchial stump with a vascularized flap is recommended . Endoscopical treatment is reserved only for small BPF associated with poor general condition ." ], "offsets": [ [ 0, 2118 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-passage-0", "type": "abstract", "text": [ "Cyclosporin A ( CSA ) nephrotoxicity is a common problem after cardiac transplantation . We have studied the impact of CSA dose reduction in association with mycophenolate mofetil ( MMF ) treatment on renal function in heart transplant recipients with suspected CSA nephrotoxicity ( serum creatinine > 2mg/dl)." ], "offsets": [ [ 0, 310 ] ] } ]

[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Cyclosporin" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" }, { "db_name": "UMLS", "db_id": "C0010594" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "transplantation" ], "offsets": [ [ 71, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029216" }, { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Cyclosporin A" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "cardiac transplantation" ], "offsets": [ [ 63, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018823" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 141, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 188, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 207, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 219, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 225, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "creatinine" ], "offsets": [ [ 289, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010294" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "mycophenolate mofetil" ], "offsets": [ [ 158, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "heart transplant" ], "offsets": [ [ 219, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018823" } ] }, { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s032.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "transplant recipients" ], "offsets": [ [ 225, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376387" } ] } ]

[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s037.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Because of the controversial discussion , even with conservative specialities , the aim of the study was to show that the surgical treatment of pulmonary metastasis is an adequate therapy with low morbidity and mortality , good survival rates and an increasing quality of life . Methods : From January 1982 until May 1992 we retrospectively reviewed all patients with pulmonary metastasis and completed follow-up until May 1995. Beside peri- and postoperative data we made a multivariant analysis to find the relevant prognostic factors and to define the survival rates . Results : Over a period of 10 years 73 patients underwent an operation for pulmonary metastasis . Follow-up was completed in 48 patients ( 21 female , 27 male ) . Median age was 47.4 years . Most primary tumors were adenocarcinoma of the colon ( n=9), renal-cell-carcinoma ( n=9), melanoma ( n=6), osteosarcoma ( n=5), and uterus carcinoma ( n=5). There were 61 operations nessecary in the 48 patients . The procedure was a lateral thoracotomy in 93.4% and a median sternotomy in 6.6% . The surgical technique was a wedge resection in 67.2% and an anatomic resection in 31.2% . 62.5% of the patients had solitary metastasis , 22.9% had 2-4 , and 14.6% had multiple metastasis . The median disease-free interval ( DFI ) of all patients was 24 months . 30 day-mortality was 1.1% ; morbidity was 3.3% . Mean hospitalization time was 11 days . The 3-year-survival of all patients was 37.5% . The following relevant prognostic factors were found : site of primary tumor ( p > 0.05 ) , number of metastasis ( p 0.05 ) , duration of DFI ( p 0.05 ) . There were significant differences in the 3-year-survival for adenocarcinomas of the colon ( 55.6% ) and osteosarcoma ( 0% ) , in multiple ( 14.3% ) and solitary metastasis ( 50% ) as well as a DFI 2 years ( 29.2% ) and > 2 years ( 45.5% ) . There were no differences in spite of the surgical technique . Conclusions : Because of low mortality and morbidity , as well as good long-term results and without satisfying conservative treatments , the surgical treatment should be favored in pulmonary metastasis . It is a safe and sure therapy for the treatment of pulmonary metastasis ." ], "offsets": [ [ 0, 2211 ] ] } ]

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[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s042.eng.abstr-passage-0", "type": "abstract", "text": [ "There is evidence that diastolic function is a major determinant of overall cardiac performance . Intraoperative use of transesophageal echocardiography ( TEE ) enables Doppler measurement of mitral inflow pattern ( E/A ratio ) . The E/A ratio is suggested to be a reliable index of changes in myocardial relaxation . In the present study we compared the time course of the E/A ratio and the time constant of myocardial relaxation ( ) assessed by direct left ventricular pressure recordings in patients before and after cardiopulmonary bypass ( CPB ) . After ethical approval , 12 patients undergoing CABG surgery were studied . Measurements of the E/A ratio and were performed after induction of anesthesia ( I ) , immediately prior to CPB with the pericardium open ( II ) , 5 min after CPB ( III ) , and after sternal closure ( IV ) . Time constant of myocardial relaxation was calculated as the reciprocal value of the slope of the left ventricular dP/dt and left ventricular pressure plot . The E/A ratio was significantly decreased at the end of surgery ( IV ) . In contrast , was increased immediately after CPB , but decreased after sternal closure ( IV ) . Cardiac index and heart rate both increased after CPB . The results of the present study demonstrate that diastolic dysfunction occurred immediately after CPB , as indicated by an increase in the time constant of myocardial relaxation . However , improved rapidly to pre-CPB values . The E/A ratio alone failed to detect the initial post-CPB alteration in left ventricular relaxation ." ], "offsets": [ [ 0, 1550 ] ] } ]

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[]

[]

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[ { "id": "ZfuerHerzThoraxGefaesschirurgie.9013s048.eng.abstr-passage-0", "type": "abstract", "text": [ "In patients receiving surgical interventions with the use of cardiopulmonary bypass , the incidence of postoperative neurological and neuropsychological dysfunction still remains high . The reasons for these disorders may be seen as multifactorial and can be divided into patient and cardiopulmonary bypass related risk factors . In this review non-invasive ( transcranial Doppler sonography , electroencephalography , infrared spectroscopy ) and invasive ( measurement of jugular venous oxygen saturation , Kety-Schmidt technique , 133Xenon-clearance technique , transcerebral double indicator dilution technique ) monitoring methods were evaluated for clinical applicability and evidence to detect cerebral hemodynamic and metabolic impairment during and after the cardiopulmonary bypass period ." ], "offsets": [ [ 0, 798 ] ] } ]

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], "normalized": [ { "db_name": "UMLS", "db_id": "C0021211" } ] } ]

[]

[]

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[ { "id": "ZfuerKardiologie.00890007.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was to evaluate the patency of coronary artery bypass grafts ( CABG ) with the 2D and 3D magnetic resonance ( MR ) imaging techniques . 29 patients with 74 bypass grafts and a total of 91 distal anastomoses were studied on a 1.5 Tesla scanner using a phased array body coil . A 2D T-2 weighted breathhold turbo spin echo sequence ( Haste ) and a 3D breath hold contrast enhanced MR angiography sequence ( Fisp-3-D) were performed . With the Haste and Fisp-3-D sequences 55 of the 58 patent and 15 of the 16 occluded grafts were recognized ; the sensitivity and specifity were 95% and 94% , respectively . With the Haste sequence 74% ( 47/63 ) and with the Fisp-3-D sequence 64% ( 40/63 ) of the distal anastomoses were seen in good image quality . Only 3 of 8 significant grafts stenoses were detected ." ], "offsets": [ [ 0, 824 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890015.eng.abstr-passage-0", "type": "abstract", "text": [ "Acute occlusion and subacute restenosis of the coronary artery are still the limiting factors of the otherwise successful interventional cardiology . Platelets and especially activated platelet populations play a key role concerning these typical and sometimes fatal complications . In this study we used flow-cytometry to determine the influence of the modern interventional technique of rotablation on platelet antigens and their possible alteration . A PTCA control group was included . We analyzed the fluorescence expression of structural antigens CD41a ( GPII-IIIa ) and CD42b ( GPIb-V-IX ) , and of the activation-dependent antigens CD62p ( P-selectin , PADGEM , GMP-140) and CD63 ( GP53). Furthermore we analyzed the binding of fibrinogen to the platelet flow-cytometrically . CD41a and CD42b did not show significant alternations in fluorescence before , directly after and thirty minutes after finishing PTCA and rotablation ( PTCA : CD41a p=0.8 and 0.9 ; CD42b p=0.5 and 0.2 ; rotablation : CD41a p=0.2 and 0.2 ; CD42b p=0.4 and 0.1 ) . But platelet activation could be detected directly after PTCA and rotablation measuring the mean channel fluorescence intensity ( MCFI ) of CD62p, CD63 and fibrinogen binding ( all p 0.05 ) . Thirty minutes after finishing the procedures there were again significant changes in MCFI in PTCA ( CD62p, CD63, fibrinogen binding ; all p 0.05 ) , but not in rotablation ( CD62p p=0.1; CD63 p=0.9; fibrinogen binding p=0.5). But MCFI for CD62p and fibrinogen binding in rotablation was higher than in PTCA . The results of our study show that rotablation also induces significant platelet activation that is higher than in PTCA alone . Flow cytometry is a sensitive and specific , multiparametric tool in establishing platelet activation . The individual platelet activation process is part of a complex cascade of events happening in the rotablated coronary segment leading to a vascular-molecular inflammatory process and consecutive clinical problems in some patients ." ], "offsets": [ [ 0, 2014 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890021.eng.abstr-passage-0", "type": "abstract", "text": [ "High restenosis rates are still a major factor limiting the use of minimal invasive coronary stenting . Tissue reactions to the implanted alloplastic endoprostheses are still barely understood . 18 coronary artery segments 32 hours up to 340 days after stent implantation of 16 patients were post-mortem investigated . The pathomorphological findings of the vessel wall after stent insertion were studied by scanning electron microscopy ( SEM ) . Stent integration can be divided with intraindividual differences in three phases : In the acute phase ( 6 weeks ) the border between vascular lumen and arterial wall is constituted by a thin , multi-layered thrombus . During the time course of integration , increasing amounts of Smooth Muscle Cells ( SMC ) and extracellular matrix can be detected . No endothelial cells can be found in the implantation zone . In the intermediate phase ( 6 weeks to 12 weeks ) the neointima consistes of extracellular matrix and increasing numbers of SMC . The borderline between lumen and neointima is generated by SMC and extracellular matrix . Increasing amounts of endothelial cells are found on the luminal surface of the stent neointima . Complete reendotheliazation is first noted in the chronic phase three months after stenting . Matrix structures are increasing whereas the amount of SMC decreases . In all phases of stent incorporation , the alloplastic stent material is coverd by a thin ( few nanometer ) proteinaceous layer ." ], "offsets": [ [ 0, 1472 ] ] } ]

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[ "time" ], "offsets": [ [ 677, 681 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "Muscle" ], "offsets": [ [ 735, 741 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "Cells" ], "offsets": [ [ 742, 747 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "Smooth Muscle" ], "offsets": [ [ 728, 741 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026843" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "extracellular matrix" ], "offsets": [ [ 760, 780 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015350" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 814, 819 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "implantation" ], "offsets": [ [ 840, 852 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029976" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "extracellular matrix" ], "offsets": [ [ 937, 957 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015350" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "extracellular matrix" ], "offsets": [ [ 1057, 1077 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015350" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 1114, 1119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 1160, 1165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s13-t1", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 1360, 1365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s13-t2", "type": "umlsterm", "text": [ "incorporation" ], "offsets": [ [ 1366, 1379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243126" } ] }, { "id": "ZfuerKardiologie.00890021.eng.abstr-s13-t3", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 1398, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] } ]

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[ { "id": "ZfuerKardiologie.00890036.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Acute myocardial infarction ( MI ) in patients with normal coronary arteries has been recognized for several years . In most cases its etiology is unknown . The objective of the present study was to describe clinical features and medium term follow-up of those patients ." ], "offsets": [ [ 0, 284 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890043.eng.abstr-passage-0", "type": "abstract", "text": [ "Patients with recurrent syncope undiagnosed after extensive noninvasive and invasive testing pose a diagnostic and therapeutic dilemma . Holter monitoring is non-diagnostic in 90% of cases . Recent developments in loop recorder technology permit longterm ECG monitoring in patients with recurrent unexplained syncope . The implantable loop recorder monitors a single lead electrogram continuously using 2 sensing electrodes on the device shell . The device was implanted in 20 patients ( 11 male , 9 female ) with the history of recurrent syncope . During a mean follow-up of 12 +/- 6 months after device implantation , 11 patients ( 55% ) experienced syncope ( 8 pts ) or presyncope ( 3 pts ) . In the remaining 9 patients , no syncope occurred . In all 11 patients with syncope or presyncope during follow-up , loop recording definitively determined whether an arrhythmia was the cause of symptoms or not . Diagnosis included bradycardia in one patient , tachycardia in two patients , in one patient two rhythm disturbances were revealed : frequent ventricular premature beats with bigemini and atrial flutter . Two patients had a neurocardiogenic syncope . Syncope was nonarrhythmic in 5 patients . An implantable loop recorder is useful for establishing the diagnosis if symptoms are recurrent but too infrequent for conventional monitoring techniques ." ], "offsets": [ [ 0, 1357 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890063.eng.abstr-passage-0", "type": "abstract", "text": [ "Notwithstanding the difficulties in definitely confirming paradoxical embolism , the association between patent foramen ovale ( PFO ) and cryptogenic stroke has repeatedly been demonstrated in clinical studies . Moreover , the recurrence rate of cerebral ischemia in patients with PFO and an unexplained stroke was found to be 3-4% per year in two recently published series . With the exception of right atrial pressure elevation in the setting of major pulmonary embolism , a reliable risk stratification of patients with PFO based on clinical or echocardiographic findings is not yet possible . The presence of atrial septal aneurysm , a wide opening of the defect during the cardiac cycle and a large atrial shunt have been implicated as risk factors by some investigators . Long-term prevention of paradoxical embolism with oral anticoagulants seems to be of questionable benefit . Besides , these agents are poorly tolerated and carry the risk of significant or fatal bleeding at a rate of 2-5% per year . Surgery of the atrial septum has been performed for many decades in patients with atrial septal defect and evidence accumulates that it is a safe and highly effective procedure in patients with PFO . At present , surgical closure of the PFO appears to be the treatment of choice for secondary prevention of paradoxical embolism . However , further studies are needed to define the appropriate candidates for surgical treatment . Devices for catheter-based sealing of PFO are also available and are currently being evaluated in clinical trials . However , experience with their use remains confined to specialized centers . Furthermore , further technical improvements of these systems are needed in order to optimize successful delivery and positioning , increase their long-term stability , and reduce periprocedural complications ." ], "offsets": [ [ 0, 1844 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890072.eng.abstr-passage-0", "type": "abstract", "text": [ "In contrast to the often debated NYHA classification , the determination of peak oxygen uptake ( peak VO2) by cardiopulmonary exercise testing allows an objective assessment of the exercise capacity of patients with congestive heart failure ( CHF ) . However , cardiopulmonary exercise testing is a time consuming and costly diagnostic tool , which requires sophisticated equipment and specially trained personell . Exercise capacity can also be determined by the 6 minute walk test . This test simply measures the distance covered by strong walking on a hallway level within 6 minutes . The 6 minute walk test is a submaximal exercise test , which is associated with much smaller increments in heart rate , blood pressure and plasma catecholamines than cardiopulmonary exercise testing . It is characterized by a very small intraindividual variance . Furthermore , it can be easily performed and , due to low logistic and personal requirements , it is very cost effective . The results of the 6 minute walk test - as well as of cardiopulmonary exercise testing - are influenced by extracardial exercise-limiting disorders , such as pulmonary diseases . Independent from the etiology of CHF , the results of the 6 minute walk test are closely related to peak VO2. In serial exercise testing the distance covered within 6 minutes allow to predict the individual peak VO2. Like peak VO2 the 6 minute walk test has been shown to be a predictor of morbidity and mortality in CHF , with its predictive value being independent from left ventricular ejection fraction and other potential prognostic parameters . In CHF patients a walking distance 300 m is associated with a one-year-mortality of up to 50% , whereas the one-year-mortality in patients reaching a walking distance > 450 m amounts to only a few percent . In addition , the hospitalization rate of patients reaching a walking distance of 300 m is several fold higher than in those with a walking distance > = 450 m . Like cardiopulmonary exercise testing , the 6 minute walk test allows to control the efficiency of specific treatments and to monitor the natural course of the disease . The 6 minute walk test is , thus , a cost effective alternative to cardiopulmonary exercise testing in CHF patients . However , neither the 6 minute walk test alone nor the results of cardiopulmonary exercise testing alone are sufficient for selecting patients , e.g. , for cardiac transplantation , as each individual case requires a synopsis of all relevant facts and parameters ." ], "offsets": [ [ 0, 2525 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890081.eng.abstr-passage-0", "type": "abstract", "text": [ "Several large scale clinical trials showed that early ACE inhibitor treatment in patients with acute myocardial infarction reduced 30-day mortality . While the short-term evidence of benefit and risks appears to be consistent among trials , scarce data are available with respect to the long-term effects of short-term treatments ." ], "offsets": [ [ 0, 331 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890093.eng.abstr-passage-0", "type": "abstract", "text": [ "Due to an improvement of results after heart transplantation , there is a continuously growing number of long-term surviving patients . Aimed at a characterization of established diagnostic and therapeutic protocols , the Working Group of Thoracic Organ Transplantation within the German Society of Cardiology performed a survey among all German heart transplantation centers . Based on the experience of 1,500 patients , the clinical relevance as well as approaches for prevention and treatment of rejection , infection , cardiac allograft vasculopathy , malignancy , hypertension , renal insufficiency , and quality of life were assessed by a questionnaire . As a result , a time dependency of expected complications could clearly be shown . While early after HTX acute rejection and infection episodes were judged as clinically important , later on cardiac allograft vasculopathy , malignancy , and renal insufficiency predominate as relevant complications . This spectrum was reflected by differentiated diagnostic protocol ( early after HTX more frequent diagnostic procedures for rejection and infection , later intensified examinations to identify cardiac allograft vascular disease and malignancy ) as well as by different intensities of immunosuppression and concomittant medication . Regarding further improvement of survival rates and quality of life , future clinical and scientific activities should be focused on the prevention of late complications after heart transplantation ." ], "offsets": [ [ 0, 1493 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890100.eng.abstr-passage-0", "type": "abstract", "text": [ "This study was performed to evaluate the role of endogenous endothelin-1 ( ET-1), atrial natriuretic peptide ( ANP ) and cyclic guanosine monophosphate ( cGMP ) in patients with left-to-right shunt and pulmonary hypertension . Further objectives were to study a possible feedback mechanism between ANP and ET-1 and to examine the influence of ANP on cGMP plasma levels . Finally , the role of these hormones in oxygen-mediated pulmonary vasodilation was examined ." ], "offsets": [ [ 0, 464 ] ] } ]

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[]

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[ { "id": "ZfuerKardiologie.00890109.eng.abstr-passage-0", "type": "abstract", "text": [ "A 54 year old women was admitted to a hospital because of acute thoracal pain , dyspnea , and clinical signs of overt right heart failure . Transthoracic and multiplane echocardiography established the diagnosis of a ruptured aneurysm of the right coronary sinus of valsalva into the right atrium which could be confirmed by cardiac catheterization . During heart surgery , which was done without complications , the defect was closed with a suture . Six months later echocardiography showed a normal right ventricle ; the function of the aortic valve was regular . Acute heart failure may be due to a congenital structural cardiac anomaly in spite of the age of 54. In such conditions transthoracic and especially transesophageal echocardiography serve as noninvasive excellent tools to make an exact diagnosis ." ], "offsets": [ [ 0, 813 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890114.eng.abstr-passage-0", "type": "abstract", "text": [ "A newborn with pulmonary atresia with ventricular septal defect and transposition of the great arteries was palliated with a modified Blalock-Taussig shunt at 5 days of age . Three days postoperatively arterial oxygen saturations dropped significantly . Thrombosis of the shunt was suspected . Angiography revealed stenosis of the proximal subclavian artery related to the creation of the shunt . The patient was successfully treated with angioplasty and stent implantation into the stenotic sublavian artery . Follow-up angiography 3 months after stent deployment showed a completely patent subclavian artery and unobstructed blood flow across the modified Blalock-Taussig shunt ." ], "offsets": [ [ 0, 681 ] ] } ]

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[]

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[ { "id": "ZfuerKardiologie.00890150.eng.abstr-passage-0", "type": "abstract", "text": [ "Three-dimensional echocardiography offers new opportunities for clinical cardiology and the solution of scientific questions . Data acquisition is possible using different techniques : ( 1 ) Realtime 3D echocardiography with matrix-array transducers is the most promising approach , but is still limited by several difficulties ; ( 2 ) 3D reconstruction is based on a number of sequentially acquired 2D image planes ( like in multiplane TEE ) , which are put together afterwards . There are 2 ways of data analysis ." ], "offsets": [ [ 0, 516 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890168.eng.abstr-passage-0", "type": "abstract", "text": [ "Augmented reality ( AR ) applications link real with virtual image data , in order to increase their information content . In medicine they are especially useful for education and for supporting the interpretation of three-dimensional ( 3D ) image data . Simulators are used to train risky or expensive procedures . In the AR application EchoCom2 a 3D surface model of the human heart is linked with echocardiographic volume data sets . The 3D echocardiographic data sets are registered with the heart model to synchronize it's temporal and spatial orientation . The heart model together with an animated ultrasound sector represents a reference scenario , which displays the currently selected cutting plane within the echocardiographic volume data set . Modifications of the cutting plane within the echocardiographic data are transferred simultaneously and in real time to the reference scenario . The AR application is used as a simulator to train two-dimensional echocardiographic examinations and as an orientation and navigation aid for the exploration of 3D echocardiographic data sets . Beginners in echocardiography have only a rudimentary conception of the spatial relationship between the actual ultrasound image and the 3D anatomy of the heart . They are unable to translate multiple two-dimensional slices into a coherent 3D mental image of the heart . In EchoCom2 the trainee can interactively explore the 3D heart model and the registered 3D echocardiographic data sets by the animated ultrasound sector , whose position is controlled by an electromagnetic orientation and position system ( EPOS ) . The data from the EPOS are used to calculate the echocardiographic images that are analogue to the position of the animated ultrasound sector . EchoCom3 is also used to support the interpretation of 3D echocardiographic data sets . The analysis of 3D echocardiographic data has to be done during a post processing . Defining the exact position of a cutting plane within the volume is difficult due to the lack of a standardized representation , the independence of the cutting plane of any transducer position and the possibility to calculate an indefinite number of views . The simultaneous representation of the current cutting plane both in the volume data , and in the heart model enables the examiner ad hoc to recognize it's position and the visualized structures ." ], "offsets": [ [ 0, 2387 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890176.eng.abstr-passage-0", "type": "abstract", "text": [ "Presently , there are no well-defined standards for documentation of echocardiographic studies . Nevertheless , standards are essential to provide comparability of data and to realize electronic communication , both essential for quality management in echocardiography ." ], "offsets": [ [ 0, 270 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890186.eng.abstr-passage-0", "type": "abstract", "text": [ "The interpretation of induced wall motion abnormalities during dobutamine stress echocardiography is affected in the case of impaired image quality ." ], "offsets": [ [ 0, 149 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890199.eng.abstr-passage-0", "type": "abstract", "text": [ "Supravalvular aortic stenosis is a rare cause of left ventricular outflow obstruction in adults . It occurs as an isolated defect sporadically or on a hereditary basis with an autosomal dominant trait without further phenotypical anomalies , or as part of the Williams syndrome with mental retardation and multiple other anomalies . This lesion was proved to result from a defect of the elastin coding gene ." ], "offsets": [ [ 0, 408 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890206.eng.abstr-passage-0", "type": "abstract", "text": [ "VEGF-A ( vascular endothelial growth factor-A ) is an endothelial-specific growth factor that stimulates endothelial function and angiogenesis . VEGF-A plays an important role during development of the vascular system , wound healing , vascularization of tumors , and for angiogenesis in ischemic tissues including the heart . VEGF-A stimulates many actions of endothelial cells including proliferation , migration , and nitric oxide release via binding to and activation of the two primarily endothelial-specific receptor-tyrosine kinases KDR and Flt-1. KDR and Flt-1 stimulate multiple signal transduction pathways in endothelial cells . This review provides an overview of the role of VEGF-A in the regulation of endothelial function , angiogenesis , and arteriogenesis with regard to activation of signal transduction pathways and their functional consequences in the endothelium . Moreover , this article discusses recent developments exploring the therapeutic potential of VEGF-A for treatment of cardiovascular diseases ." ], "offsets": [ [ 0, 1028 ] ] } ]

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"UMLS", "db_id": "C0018284" } ] }, { "id": "ZfuerKardiologie.00890206.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "VEGF-A" ], "offsets": [ [ 145, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0911658" } ] }, { "id": "ZfuerKardiologie.00890206.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 171, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerKardiologie.00890206.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "ZfuerKardiologie.00890206.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "wound" ], "offsets": [ [ 220, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021501" }, { "db_name": "UMLS", "db_id": "C0043250" } ] }, { "id": "ZfuerKardiologie.00890206.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 255, 261 ] ], 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[]

[]

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[ { "id": "ZfuerKardiologie.00890219.eng.abstr-passage-0", "type": "abstract", "text": [ "Reduced activity of the endogenous fibrinolytic system contributes to intramural deposition of microthrombi in atherogenesis and to intraluminal deposition of thrombi leading to acute complications of atherosclerosis such as acute coronary syndromes . Endogenous fibrinolytic activity is predominantly regulated by the plasminogen activator inhibitor type 1 ( PAI-1). Increased activity of PAI-1 leading to reduced endogenous fibrinolytic activity has been identified as an important independent risk factor for cardiovascular disease . Vascular endothelial cells form a barrier between the circulating blood with its dynamic balance between ongoing thrombosis and fibrinolysis and the subendothelial layers of the vascular wall with their prothrombotic activity . In addition , endothelial cells synthesize and secrete substantial amounts of plasminogen activators and their inhibitor PAI-1. Thus , endothelium plays an important role in the regulation of endogenous fibrinolysis . After describing the components of the endogenous fibrinolytic system and its interactions , this review focuses on the impact on endogenous fibrinolysis by the renin angiotensin system , the kallikrein kinin system , and type 2 diabetes mellitus . Investigations using transgenic and knock-out animal models - the results of which are also summarized - have improved our understanding of the interaction between endogenous fibrinolysis and endothelium . In each section of the review therapeutic implications and potentials are discussed ." ], "offsets": [ [ 0, 1523 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890227.eng.abstr-passage-0", "type": "abstract", "text": [ "The main symptoms of chronic heart failure are dyspnoe and exercise intolerance . The pathophysiological basis of these symptoms is not simply the dysfunction of the heart , but a complex interaction of the central circulation , the peripheral vessels , the skeletal muscles , the ventilatory , and the endocrine system . In contrast to acute heart failure , where bedrest is known to be beneficial , prolonged limitation of physical activity can be detrimental in the chronic stage of the disease . Therefore , since the 1980s there have been several reports about heart failure patients participating in exercise programs . The results were encouraging : the physiological gains were impressive , and contrary to prior fears , in the great majority of reports no deterioration of the cardiac function could be observed . The net result of training in this condition is an improvement in exercise capacity in the range of the best pharmacological treatment . In detail , blood flow into the working muscle is increased , the ventilation for each given workload is reduced , the skeletal muscle overall function ( including biochemical and histological aspects ) is improved , the increased neurohormonal activity - especially of the sympathicoadrenergic system - will be normalized , and the patient's quality of life is significantly improved . Whether all of these beneficial aspects will result in improved survival is not yet proven , although one recent study provides some evidence in this direction . But even if today no definite answer to this question from a large , multicenter trial is available , application of exercise training for selected heart failure patients can be recommended , if adequate supervision is provided ." ], "offsets": [ [ 0, 1738 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890239.eng.abstr-passage-0", "type": "abstract", "text": [ "Angiogenesis is the growth of new vessels from preexisting vessels by sprouting and intussusception with ischemia being the major stimulus . Circulating endothelial precursor cells have recently been found to participate in this process . The remodeling of preexisting bridging collateral arterioles , i.e. , arteriogenesis , should be a much more efficient mechanism to compensate for the gradual or intermittent occlusion of a major epicardial or peripheral artery . Arteriogenesis is associated with an active growth process . It is probably not dependent on ischemia but initiated by local hemodynamic and mechanical effects on the vessel that occur with increasing blood flow . A variety of growth factors that act not only by stimulating endothelial and smooth muscle cell proliferation and migration , as well as substances that increase recruitment and activation of monocytes have been demonstrated to stimulate angiogenesis and arteriogenesis . Several clinical phase I trials suggest the feasibility and short-term safety of treatment with growth factors or their genes . The VIVA trial , the only phase II trial that has been published in this field , employed VEGF165 by intracoronary infusion followed by several intravenous infusions and did not demonstrate any increase of exercise time or angina by VEGF over placebo . The strong sustained placebo effect was surprising . Concerns about the long-term exacerbation of angiogenesis-dependent pathologic processes , like malignant tumors , atherosclerotic plaque formation and proliferative retinopathies , will require careful follow-up . Pro-angiogenic and pro-arteriogenic therapies may need further sophistication before they enter clinical practice ." ], "offsets": [ [ 0, 1719 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890259.eng.abstr-passage-0", "type": "abstract", "text": [ "In the following , three newer concepts are brought together : myocardial hibernation , heterogeneity in myocardial blood flow and oxidative metabolism , and effects of hibernating animal serum on non-hibernators ." ], "offsets": [ [ 0, 214 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890264.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the discovery of renin by Tigerstedt and Bergmann , the renin angiotensin system ( RAS ) has been recognized as an important modulator of blood pressure and volume homeostasis . Based on these functions a pathophysiological role of the RAS in the pathogenesis of hypertension and other cardiovascular disorders has been postulated . The therapeutic benefit of RAS inhibition by angiotensin converting enzyme ( ACE ) inhibitors and angiotensinII ( ANGII ) antagonists in these conditions has been shown . It remains unclear , however , whether the changes in RAS activity associated with cardiovascular disease are primary or secondary factors . It is well known that hypertension and hypertensive end-organ disease is influenced by genetic factors . Gene polymorphisms for virtually all components of the RAS have been described and investigated in clinical studies . It remains to be determined , however , how relevant these findings are for disease etiology . This review , therefore , will attempt to discuss the causal implications of these genetic studies for cardiovascular disease . The role of angiotensinogen and ACE for hypertension , coronary artery disease and other cardiovascular disorders is discussed in this context in an exemplary fashion ." ], "offsets": [ [ 0, 1265 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890269.eng.abstr-passage-0", "type": "abstract", "text": [ "Recently intra-atrial defibrillation has become an interesting alternative to external defibrillation and drug therapy for the treatment of atrial fibrillation . Low-energy intra-atrial defibrillation can be used to restore sinus rhtyhm f.ex. after a failed external cardioversion or during an electrophysiologic study when the administration of antiarrhythmic drugs should be avoided . Additionally this new technique has led to the development of implantable atrial defibrillators for the treatment of selected patients suffering from chronic atrial fibrillation . Intra-atrial defibrillation seems to be a highly effective and safe method , but little experience exists concerning the outcome so far . Especially the potential risk of inducing ventricular proarrhythmia is subject of current controversy ." ], "offsets": [ [ 0, 808 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890284.eng.abstr-passage-0", "type": "abstract", "text": [ "The objective of this open , randomized , multicenter study is to investigate the benefits and economic efficiency of self-management of oral anticoagulation in patients with atrial fibrillation ( SMAAF study ) in comparison with a group of patients given conventional care by a general practitioner or specialist . Two thousand patients suitable for self-management will be assigned at random to either the self-management group or the control group . The numbers of thromboembolic and hemorrhagic complications requiring treatment during the 2-year follow-up period will be recorded as the primary end point . The secondary endpoint variables will be maintenance of the INR value in the individual target range , INR variance , the course of complications over time , and the cost efficiency of self-management compared with the routine procedures . The last of these parameters will include the diagnostic and/or therapeutic measures carried out , the duration of inpatient hospital treatment , and the social consequences ( subsequent rehabilitation treatment , inability to work , forced rentirement ) . The estimate of the required number of patients was based on the assumption that during long-term anticoagulant therapy within the framework of primary and secondary prevention 4% of patients with chronic non-valvular atrial fibrillation would have severe thromboembolic of hemorrhagic complications each year . Since this rate can be halved by self-management , a one-tailed 2-test of 80% power and a 5% significance threshold would require n = 997 patients per group . The results of the SMAAF study will establish the socioeconomic benefits of selfmanagement in patients with non-valvular atrial fibrillation ." ], "offsets": [ [ 0, 1722 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890289.eng.abstr-passage-0", "type": "abstract", "text": [ "Aim of our study was the comparison of bipolar ECG quality ( with a 4cm lead distance ) at different sites within the anterior thorax to find the preferable implantation site for an ECG event recorder ( ECG-ER ) ." ], "offsets": [ [ 0, 213 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890295.eng.abstr-passage-0", "type": "abstract", "text": [ "\" Idiopathic \" ventricular tachycardia is an exclusion diagnosis . The underlying reasons and mechanisms of \" idiopathic \" ventricular tachycardias are still not completely understood . Recent investigations showed a high prevalence of morphological abnormalities in the right ventricle of patients with \" idiopathic \" ventricular tachycardia out of the right ventricular outflow tract , which could often be correlated with the origin of the ventricular tachycardia . These described abnormalities were not uniform . Here we report about a patient suffering from drug-refractory \" idiopathic \" ventricular tachycardia for 10 years . This is the first report in which the origin of an \" idiopathic \" ventricular tachycardia could be localized by right-ventricular angiography , magnetic resonance tomography and electrophysiological study in the area of an interventricular septal thickening of the right ventricular outflow tract and cured by radiofrequency catheter ablation ." ], "offsets": [ [ 0, 978 ] ] } ]

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[ { "id": "ZfuerKardiologie.00890301.eng.abstr-passage-0", "type": "abstract", "text": [ "In contrast to the luminogram of coronary angiography , intravascular ultrasound ( IVUS ) has proven to accurately assess both coronary lumen and vessel morphology due to its 360 ° imaging capacity . Directional coronary atherectomy ( DCA ) improves the coronary lumen by removing plaque mass rather than stretching the vessel and compressing the plaque as with conventional percutaneous transluminal coronary angioplasty . In an attempt to optimize the procedural result of DCA we prospectively investigated the impact of IVUS guidance in a head to head comparison to on-line quantitative coronary angiography ( QCA ) on the result of DCA . In 16 consecutive patients IVUS demonstrated significant residual plaque mass after DCA irrespective of a satisfactory angiographic result . After a mean of 9 +/- 2 cuts luminal improvement was obtained with an area stenosis by angiography of 39 +/- 17% and by IVUS of 50 +/- 10% ( p 0.05 ) , a diameter stenosis by angiography of 23 +/- 10% and IVUS of 35 +/- 14% ( p 0.05 ) and finally a minimal lumen diameter ( MLD ) by angiography of 2.9 +/- 0.5 mm and by IVUS of 2.3 +/- 0.5 mm ( p 0.005 ) . After both on-line QCA and IVUS measurements a second series of 7 +/- 2 cuts were initiated to debulk more atheroma and improve stenosis dimensions . After additional cuts IVUS revealed further luminal improvement with an area stenosis by angiography of 25 +/- 16% and IVUS of 21 +/- 18% ( n.s. ) , a diameter stenosis by angiography of 16 +/- 11% and by IVUS of 13 +/- 19% ( n.s. ) and finally a MLD by angiography of 3.1 +/- 0.5 mm and by IVUS of 2.8 +/- 0.3mm ( p 0.05 ) . Intraprocedual use of IVUS is superior to on-line QCA to assess the immediate result of DCA . IVUS-guided DCA results in more effective atheroma debulking than luminographic evaluation . Results of larger follow-up studies are needed to substantiate the intraprocedural advantage of IVUS with DCA ." ], "offsets": [ [ 0, 1914 ] ] } ]

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[]

[]

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[ { "id": "ZfuerKardiologie.00890307.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : A fractional flow reserve ( FFRmyo ) 0.75 is a well validated parameter for significance of coronary stenoses in cases of normal myocardial function . We used the FFRmyo limit in patients with impaired myocardial perfusion by myocardial infarction and/or hypertension for intermediate stenoses of the LAD for decision to PTCA and checked the indication by clinical follow-up ." ], "offsets": [ [ 0, 389 ] ] } ]

[ { "id": "ZfuerKardiologie.00890307.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 153, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 226, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031001" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 250, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 268, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "PTCA" ], "offsets": [ [ 334, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002997" } ] }, { "id": "ZfuerKardiologie.00890307.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 239, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] } ]

[]

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[ { "id": "ZfuerKardiologie.00890316.eng.abstr-passage-0", "type": "abstract", "text": [ "Abstract Periperal embolisation is a typical complication of catheter interventions in degenerated aorto-coronary saphenous vein grafts . Alternative techniques , such as transluminal extraction catheter ( TEC ) , directional coronary athrectomy ( DCA ) and eximer laser angioplasty ( ELCA ) were not able to reduce the risk of peripheral vessel occlusion or \" no-reflow \" . For the protection from peripheral embolisation we used the PercuSurge GuardWireTM Temporary Occlusion & Aspiration System ( PercuSurge Inc. , Sunnyvale , USA ) in 55 patients with 58 stenosis in degenerated saphenous vein grafts . The primary endpoint of this consecutive series was to access the efficacy of the system by postinterventional TIMI flow and determination of serial CK/CK-MB . The intervention was primarily successful in 55 of 58 cases ( 94.8% ) , with a reduction in stenosis from 87.6% ( range 75-100% ) to 4.5% ( range 0-40% ) . TIMI flow improved from a mean of 2.1 +/- 1.4 to 2.9 +/- 0.4 after intervention . CK/CK-MB levels were 24/5 , 27/7 and 26/6U/l ( mean values ) before , 8 hours , 16 hours and 24 hours after intervention , ruling out myocardial ischemia . Three ( 5.2% ) non-q wave infarctions occured in this series , twice caused by a peripheral embolisation during the crossing of the lesion with the wire und once because of \" no-reflow \" . In the latter case the occlusion balloon had to be deflated before the aspiration could be performed . In 80 of 92 aspirates ( 86.9% ) macroscopic embolic debris was visible . The PercuSurge GuardWireTM Temporary Occlusion & Aspiration System is a safe and effective device for the protection of distal embolisation during interventions in degenerated aorto-coronary saphenous vein grafts ." ], "offsets": [ [ 0, 1740 ] ] } ]

[ { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Abstract" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000857" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "embolisation" ], "offsets": [ [ 19, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013931" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 45, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "catheter" ], "offsets": [ [ 61, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "vein" ], "offsets": [ [ 124, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "grafts" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "saphenous vein" ], "offsets": [ [ 114, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036186" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 150, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "catheter" ], "offsets": [ [ 195, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 265, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "angioplasty" ], "offsets": [ [ 271, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162577" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "ELCA" ], "offsets": [ [ 285, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006754" }, { "db_name": "UMLS", "db_id": "C0006675" }, { "db_name": "UMLS", "db_id": "C0050385" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 320, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 339, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "laser angioplasty" ], "offsets": [ [ 265, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0078950" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 320, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "embolisation" ], "offsets": [ [ 410, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013931" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "Aspiration" ], "offsets": [ [ 480, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004056" }, { "db_name": "UMLS", "db_id": "C0004048" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 542, 550 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 559, 567 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "vein" ], "offsets": [ [ 593, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "grafts" ], "offsets": [ [ 598, 604 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "saphenous vein" ], "offsets": [ [ 583, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036186" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "determination" ], "offsets": [ [ 732, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerKardiologie.00890316.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "serial" ], "offsets": [ [ 749, 755 ] ], "normalized": [ { "db_name": 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[]

[]

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[ { "id": "ZfuerKardiologie.00890330.eng.abstr-passage-0", "type": "abstract", "text": [ "In acute myocardial infarction intracoronary stenting is superior to PTCA regarding interventional success and occurrence of cardiac events . It is , however , uncertain whether myocardial function also improves with stenting . We , therefore , assessed angiographic parameters of myocardial function in patients with acute myocardial infarction who were treated with primary PTCA and received additional stenting in case of an unsatisfactory angiographic result ( provisional stenting ) ." ], "offsets": [ [ 0, 489 ] ] } ]

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[]

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